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High-voltage (HV) pulse generators (PGs) are the core of pulsed electric field applications. Applying HV pulses produces electrical pores in a biological cell membrane, in which if the size of the pores increases beyond a critical size, the cell will not survive. This paper proposes a new HV-PG based on the modular multilevel converter with full-bridge submodules (FB-SMs). In order to alleviate the need of complicated sensorless or sensor-based voltage balancing techniques for the FB-SM capacitors, a dedicated self-regulating charging circuit is connected across each FB-SM capacitor. The individual capacitor charging voltage level is obtained from three successive stages, namely, convert the low-voltage dc input voltage to a high-frequency square ac voltage, increase the ac voltage level via a nanocrystalline step-up transformer, and rectify the secondary transformer ac voltage via a diode FB rectifier. The HV bipolar pulses are formed across the load in a fourth stage through series connected FB-SMs. The flexibility of inserting and bypassing the FB-SM capacitors allows the proposed topology to generate different pulse-waveform shapes, including rectangular waveforms with specifically reduced dv/dt and ramp pulses. The practical results, from a scaled-down experimental rig with five FB-SMs and a 1-kV peak-to-peak pulse output, validate the proposed topology. [ABSTRACT FROM PUBLISHER]

Repetitive high pulsed electric field (PEF) is an effective method to kill microorganisms and bacteria in water treatment applications. The PEF can be generated by applying high-power electromagnetic pulse across the sample to be treated. There are two main types of high-voltage pulse generators, namely, unipolar and bipolar. In this paper, a full-bridge submodule-based modular high-voltage pulse generator, having the ability to generate unipolar and bipolar high-voltage pulses with different shapes from a relatively low-voltage input dc supply, is proposed. In the proposed configuration, relatively low-voltage insulated gate bipolar transistors (IGBTs) are required to generate the high-voltage bipolar pulses. A thyristor rated at the level of the pulsed output voltage is required in the proposed configuration to bypass the load during the charging process of capacitors. In the proposed approach, a thyristor is used instead of the self-commutated high-voltage switch (e.g., series-connected IGBTs), as thyristors are available with high-voltage ratings and possess inherent reverse voltage blocking capability. A detailed illustration of the proposed configuration and its operational concept are introduced in this paper. Simulation and experimental results are presented to validate the proposed approach. [ABSTRACT FROM AUTHOR]