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High-voltage (HV) pulse generators (PGs) are the core of pulsed electric field applications. Applying HV pulses produces electrical pores in a biological cell membrane, in which if the size of the pores increases beyond a critical size, the cell will not survive. This paper proposes a new HV-PG based on the modular multilevel converter with full-bridge submodules (FB-SMs). In order to alleviate the need of complicated sensorless or sensor-based voltage balancing techniques for the FB-SM capacitors, a dedicated self-regulating charging circuit is connected across each FB-SM capacitor. The individual capacitor charging voltage level is obtained from three successive stages, namely, convert the low-voltage dc input voltage to a high-frequency square ac voltage, increase the ac voltage level via a nanocrystalline step-up transformer, and rectify the secondary transformer ac voltage via a diode FB rectifier. The HV bipolar pulses are formed across the load in a fourth stage through series connected FB-SMs. The flexibility of inserting and bypassing the FB-SM capacitors allows the proposed topology to generate different pulse-waveform shapes, including rectangular waveforms with specifically reduced dv/dt and ramp pulses. The practical results, from a scaled-down experimental rig with five FB-SMs and a 1-kV peak-to-peak pulse output, validate the proposed topology. [ABSTRACT FROM PUBLISHER]

In order to generate bipolar high-voltage (HV) pulses across certain load from HV dc (HVdc) power supply, a voltage source inverter (VSI) stage should be inserted between the load and the supply. In order to meet the required HV level, series connection of semiconductor devices should be employed with dynamic voltage sharing between the involved devices. Modular multilevel converter (MMC) can be used instead of the conventional two-level VSI to alleviate the complexity introduced by the deployment of series-connected devices. The voltage level of the HVdc power supply and the voltage rating of the available semiconductor devices determine the suitable number of MMC voltage levels ( $N$ ). Capacitor voltage balancing is a vital issue for proper operation of the MMC. In general, conventional sensor-based balancing techniques require a significant amount of measurements, which increases the complexity of the system. In addition, the high dv/dt during switching times causes electromagnetic interference, which may adversely affect the accuracy of the measurements. In this paper, a sensorless voltage balancing technique is proposed for the MMC-based bipolar HV pulse generator that reduces the system sensitivity, cost, and complexity. A detailed illustration of the proposed approach is presented in this paper. The simulation and experimental results are used to validate the proposed concept. [ABSTRACT FROM AUTHOR]