1. Ultrasonic assessment of extracellular matrix content in healing achilles tendon
- Author
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Sleiman R. Ghorayeb, Nadeen O. Chahine, Pasquale Razzano, Folorunsho Edobor-Osula, Daniel A. Grande, Lewis B. Lane, and Neil V. Shah
- Subjects
Male ,musculoskeletal diseases ,Acoustics and Ultrasonics ,Achilles Tendon ,Rats, Sprague-Dawley ,Extracellular matrix ,Tendon Injuries ,Image Processing, Computer-Assisted ,Extracellular ,Animals ,Medicine ,Electrical and Electronic Engineering ,Instrumentation ,Tendon healing ,Ultrasonography ,Wound Healing ,Achilles tendon ,business.industry ,Ultrasound ,Biomechanics ,musculoskeletal system ,Biomechanical Phenomena ,Extracellular Matrix ,Rats ,medicine.anatomical_structure ,Linear Models ,Ultrasonic sensor ,business ,Wound healing ,Biomedical engineering - Abstract
Although several imaging modalities have been utilized to observe tendons, assessing injured tendons by tracking the healing response over time with ultrasound is a desirable method which is yet to be realized. This study examines the use of ultrasound for non-invasive monitoring of the healing process of Achilles tendons after surgical transection. The overall extracellular matrix content of the transection site is monitored and quantified as a function of time. B-mode images (built from successive A-scan signatures) of the injury site were obtained and compared to biomechanical properties. A quantitative measure of tendon healing using the extracellular matrix (ECM) content of the injury site was analyzed using linear regression with all biomechanical measures. Contralateral tendons were used as controls. The trend in the degree of ECM regrowth in the 4 weeks following complete transection of excised tendons was found to be most closely paralleled with that of linear stiffness (R2 = 0.987, p
- Published
- 2012
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