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The optimization of train trajectory and timetable offers two effective methods of energy-efficient operations. Most traditional research optimizes them separately and thus the global optimality cannot be achieved. Previous work has mainly concentrated on minimizing the mechanical energy consumption of trains, not the electrical energy. This paper aims to develop an integrated model to optimize the integrated timetable, which includes both the timetable and the train trajectory achieve the minimum electrical energy consumption. The AC power supply system model is first proposed to calculate the parameters of the AC power supply network. Then, a model is developed to calculate various energy consumptions using power flow calculation. Furthermore, an integrated timetable optimization model for minimum total energy consumption of AC railway system is proposed and the optimal integrated timetable is obtained by the proposed hybrid GA-PSO algorithm. Finally, 5 real-world case studies based on the Lanzhou–Xinjiang high-speed railway are presented. The results show that the proposed integrated model can achieve a reduction in total energy consumption for the entire line up to 14.3% compared with the previous optimization model. The hybrid GA-PSO algorithm achieves the best results compared with the results achieved by the GA and PSO algorithms applied along. [ABSTRACT FROM AUTHOR]