1. Simple Nonlinear Models for Glucose-Insulin Dynamics: Application to Intraperitoneal Insulin Infusion
- Author
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Claudia Lopez-Zazueta, Anders Lyngvi Fougner, and Øyvind Stavdahl
- Subjects
0209 industrial biotechnology ,medicine.medical_treatment ,02 engineering and technology ,Artificial pancreas ,Medical technology: 620 [VDP] ,020901 industrial engineering & automation ,Parameter estimation ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Systemidentifikasjon ,System identification ,Medisinsk teknologi: 620 [VDP] ,Mathematics ,Type 1 diabetes ,Estimation theory ,Insulin ,020208 electrical & electronic engineering ,Linear model ,medicine.disease ,Parameterestimering ,Medical cybernetics ,Nonlinear system ,Control and Systems Engineering ,Medisinsk kybernetikk ,Identifiability ,Biological system - Abstract
The design of a model-based control method for an Artificial Pancreas requires a relatively simple and identifiable mathematical model to control glucose levels through hormone delivery. In this work we introduce new, simple nonlinear models to simulate data from experiments where insulin boluses are administrated in the peritoneal cavity. The models account for the delay between insulin administration and its nonlinear transport to other compartments. They were calibrated using experimental data from pigs. The results show that the suggested models are able to describe the data well, with average BIC value of 145. Moreover, the new models were compared with a common linear model which was not able to describe the data well, with BIC value of 920. They were also compared with a common nonlinear model which failed to represent insulin increases in the data and had BIC value of 637. Finally, profile likelihoods were applied for assessing the identifiability of one of the new models. © 2019, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd.
- Published
- 2019
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