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1. T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Author

Briukhovetska, Daria, primary, Suarez-Gosalvez, Javier, additional, Voigt, Cornelia, additional, Markota, Anamarija, additional, Giannou, Anastasios D., additional, Schübel, Maryam, additional, Jobst, Jakob, additional, Zhang, Tao, additional, Dörr, Janina, additional, Märkl, Florian, additional, Majed, Lina, additional, Müller, Philipp Jie, additional, May, Peter, additional, Gottschlich, Adrian, additional, Tokarew, Nicholas, additional, Lücke, Jöran, additional, Oner, Arman, additional, Schwerdtfeger, Melanie, additional, Andreu-Sanz, David, additional, Grünmeier, Ruth, additional, Seifert, Matthias, additional, Michaelides, Stefanos, additional, Hristov, Michael, additional, König, Lars M., additional, Cadilha, Bruno Loureiro, additional, Mikhaylov, Oleg, additional, Anders, Hans-Joachim, additional, Rothenfusser, Simon, additional, Flavell, Richard A., additional, Cerezo-Wallis, Daniela, additional, Tejedo, Cristina, additional, Soengas, María S., additional, Bald, Tobias, additional, Huber, Samuel, additional, Endres, Stefan, additional, and Kobold, Sebastian, additional

Published
2023
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2. Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

Author

Giannou, Anastasios D., primary, Kempski, Jan, additional, Shiri, Ahmad Mustafa, additional, Lücke, Jöran, additional, Zhang, Tao, additional, Zhao, Lilan, additional, Zazara, Dimitra E., additional, Cortesi, Filippo, additional, Riecken, Kristoffer, additional, Amezcua Vesely, Maria Carolina, additional, Low, Jun Siong, additional, Xu, Hao, additional, Kaffe, Eleanna, additional, Garcia-Perez, Laura, additional, Agalioti, Theodora, additional, Yamada, Yoshito, additional, Jungraithmayr, Wolfgang, additional, Zigmond, Ehud, additional, Karstens, Karl-Frederick, additional, Steglich, Babett, additional, Wagner, Jonas, additional, Konczalla, Leonie, additional, Carambia, Antonella, additional, Schulze, Kornelius, additional, von Felden, Johann, additional, May, Peter, additional, Briukhovetska, Daria, additional, Bedke, Tanja, additional, Brockmann, Leonie, additional, Starzonek, Sarah, additional, Lange, Tobias, additional, Koch, Claudia, additional, Riethdorf, Sabine, additional, Pelczar, Penelope, additional, Böttcher, Marius, additional, Sabihi, Morsal, additional, Huber, Francis J., additional, Reeh, Matthias, additional, Grass, Julia Kristin, additional, Wahib, Ramez, additional, Seese, Hannes, additional, Stüben, Björn-Ole, additional, Fard-Aghaie, Mohammad, additional, Duprée, Anna, additional, Scognamiglio, Pasquale, additional, Plitzko, Gabriel, additional, Meiners, Jan, additional, Soukou, Shiwa, additional, Wittek, Agnes, additional, Manthey, Caroline, additional, Maroulis, Ioannis C., additional, Arck, Petra C., additional, Perez, Daniel, additional, Gao, Bin, additional, Zarogiannis, Sotirios G., additional, Strowig, Till, additional, Pasqualini, Renata, additional, Arap, Wadih, additional, Gosálvez, Javier Suárez, additional, Kobold, Sebastian, additional, Prinz, Immo, additional, Guse, Andreas H., additional, Tachezy, Michael, additional, Ghadban, Tarik, additional, Heumann, Asmus, additional, Li, Jun, additional, Melling, Nathaniel, additional, Mann, Oliver, additional, Izbicki, Jakob R., additional, Pantel, Klaus, additional, Schumacher, Udo, additional, Lohse, Ansgar W., additional, Flavell, Richard A., additional, Gagliani, Nicola, additional, and Huber, Samuel, additional

Published
2023
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3. Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation

Author

Emgård, Johanna, Kammoun, Hana, García-Cassani, Bethania, Chesné, Julie, Parigi, Sara M., Jacob, Jean-Marie, Cheng, Hung-Wei, Evren, Elza, Das, Srustidhar, Czarnewski, Paulo, Sleiers, Natalie, Melo-Gonzalez, Felipe, Kvedaraite, Egle, Svensson, Mattias, Scandella, Elke, Hepworth, Matthew R., Huber, Samuel, Ludewig, Burkhard, Peduto, Lucie, Villablanca, Eduardo J., Veiga-Fernandes, Henrique, Pereira, João P., Flavell, Richard A., and Willinger, Tim

Published
2018
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7. Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney

Author

Krebs, Christian F., primary, Paust, Hans-Joachim, additional, Krohn, Sonja, additional, Koyro, Tobias, additional, Brix, Silke R., additional, Riedel, Jan-Hendrik, additional, Bartsch, Patricia, additional, Wiech, Thorsten, additional, Meyer-Schwesinger, Catherine, additional, Huang, Jiabin, additional, Fischer, Nicole, additional, Busch, Philipp, additional, Mittrücker, Hans-Willi, additional, Steinhoff, Ulrich, additional, Stockinger, Brigitta, additional, Perez, Laura Garcia, additional, Wenzel, Ulrich O., additional, Janneck, Matthias, additional, Steinmetz, Oliver M., additional, Gagliani, Nicola, additional, Stahl, Rolf A.K., additional, Huber, Samuel, additional, Turner, Jan-Eric, additional, and Panzer, Ulf, additional

Published
2016
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8. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

Author

Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, Burg J, Strand S, Kiesslich R, Huber S, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Galle PR, Blessing M, Rose-John S, and Neurath MF

Subjects
Animals, Blotting, Western, Colonic Neoplasms immunology, Colonic Neoplasms pathology, DNA-Binding Proteins immunology, DNA-Binding Proteins metabolism, Disease Models, Animal, Disease Progression, Endoscopy, Digestive System, Enzyme-Linked Immunosorbent Assay, Humans, Immunohistochemistry, Interleukin-6 immunology, Intestinal Mucosa immunology, Intestinal Mucosa metabolism, Mice, Mice, Knockout, Mice, Transgenic, Protein Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Interleukin-6 immunology, Receptors, Interleukin-6 metabolism, Receptors, Transforming Growth Factor beta genetics, Receptors, Transforming Growth Factor beta immunology, Receptors, Transforming Growth Factor beta metabolism, Recombinant Fusion Proteins immunology, Recombinant Fusion Proteins metabolism, Reverse Transcriptase Polymerase Chain Reaction, STAT3 Transcription Factor, Trans-Activators immunology, Trans-Activators metabolism, Transforming Growth Factor beta genetics, Transforming Growth Factor beta immunology, Colonic Neoplasms metabolism, Interleukin-6 metabolism, Signal Transduction physiology, T-Lymphocytes immunology, Transforming Growth Factor beta metabolism
Abstract

Alterations of TGF-beta signaling have been described in colorectal cancer, although the molecular consequences are largely unknown. By using transgenic mice overexpressing TGF-beta or a dominant-negative TGF-betaRII, we demonstrate that TGF-beta signaling in tumor infiltrating T lymphocytes controls the growth of dysplastic epithelial cells in experimental colorectal cancer, as determined by histology and a novel system for high-resolution chromoendoscopy. At the molecular level, TGF-beta signaling in T cells regulated STAT-3 activation in tumor cells via IL-6. IL-6 signaling required tumor cell-derived soluble IL-6R rather than membrane bound IL-6R and suppression of such TGF-beta-dependent IL-6 trans-signaling prevented tumor progression in vivo. Taken together, our data provide novel insights into TGF-beta signaling in colorectal cancer and suggest novel therapeutic approaches for colorectal cancer based on inhibition of TGF-beta-dependent IL-6 trans-signaling.

Published
2004
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