1. Driving Rel-iant Tregs toward an Identity Crisis.
- Author
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Li, Amy and Jacks, Tyler
- Subjects
- *
CELL physiology , *CANCER cell growth , *IMMUNOSUPPRESSION , *TUMOR microenvironment , *T cells - Abstract
Inhibiting Treg cell function in tumors is an attractive strategy to improve anti-cancer immunity. In a pair of papers in Immunity and Cell , Ghosh and colleagues show that the canonical NF-κB subunits p65 and c-Rel have non-redundant, critical roles in promoting Treg cell development and function ( Oh et al., 2017 ). Targeting c-Rel blunts Treg cell immunosuppressive activity in the tumor microenvironment and enhances anti-tumor T cell responses ( Grinberg-Bleyer et al., 2017 ). [ABSTRACT FROM AUTHOR]
- Published
- 2017
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