1. Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn's disease, respectively
- Author
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Koji Sawada, K. Tamura, Masamichi Satomi, Kazuo Tamura, Tadashi Kosaka, Hiroko Bamba, Hiroko Sashio, Yoshihiro Fukuda, Takashi Shimoyama, Yoshihiro Yamamoto, Reiko Ito, Shin Fukui, and Jun-ichi Furuyama
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Adult ,Male ,Adolescent ,Immunology ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Inflammatory bowel disease ,Receptors, Tumor Necrosis Factor ,Exon ,Crohn Disease ,Gene Frequency ,Antigens, CD ,Genetics ,medicine ,Humans ,Receptors, Tumor Necrosis Factor, Type II ,Child ,Gene ,Alleles ,Aged ,Crohn's disease ,Tumor Necrosis Factor-alpha ,Haplotype ,Middle Aged ,medicine.disease ,Ulcerative colitis ,Haplotypes ,Receptors, Tumor Necrosis Factor, Type I ,Case-Control Studies ,Colitis, Ulcerative ,Female ,Tumor necrosis factor alpha - Abstract
The importance of tumor necrosis factor (TNF)-alpha and the TNF receptor gene polymorphisms in the etipathogenesis of inflammatory bowel disease (IBD) has not been elucidated. DNA from peripheral blood samples was obtained from 124 patients with Crohn's disease (CD), 106 patients with ulcerative colitis (UC), and 111 unrelated healthy controls. We examined two single nucleotide polymorphisms (SNPs) of the TNF-alpha gene, TNF (–308 G/A and –238 G/A), an SNP of the TNF receptor superfamily member 1A gene, TNFRSF1A(also known as TNFR1), at codon 12 in exon 1 (CCA/CCG), and two SNPs of the 1B gene, TNFRSF1B (also known as TNFR2), (1466 A/G and 1493 C/T). There was a difference in the carrier frequency for haplotype AG (–308 A, –238 G) between UC patients and the controls (OR=4.76, 95% CI=1.53–14.74, P
- Published
- 2002
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