1. Keratinocytes produce IL-6 in response to desmoglein 1 cleavage by Staphylococcus aureus exfoliative toxin A
- Author
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Lisa R. W. Plano, Juan Chen, Richard V. Snyder, Irena Pastar, Cleo E. Rolle, Roberto Perez, Franco Ferracci, Marjana Tomic-Canic, Suzanne Hower, and Tatiana C. Cardenas
- Subjects
Keratinocytes ,Methicillin-Resistant Staphylococcus aureus ,Staphylococcus aureus ,Virulence Factors ,Immunology ,Leukocidin ,Virulence ,Biology ,medicine.disease_cause ,Microbiology ,Cell Line ,Immune system ,medicine ,Leukocytes ,Animals ,Humans ,Staphylococcus aureus delta toxin ,Pathogen ,Toxin ,Interleukin-6 ,Desmoglein 1 ,biochemical phenomena, metabolism, and nutrition ,respiratory system ,bacterial infections and mycoses ,Staphylococcal scalded skin syndrome ,medicine.disease ,Exfoliatins ,Proteolysis ,Staphylococcal Skin Infections ,Epidermis ,circulatory and respiratory physiology - Abstract
Many skin infections are caused by Staphylococcus aureus, a bacterial pathogen that produces virulence factors associated with these conditions such as exfoliative toxins A and B (ETA, ETB) and the leukotoxin Panton–Valentine leukocidin (PVL). Herein, we examine the potential of skin-infecting S. aureus to produce virulence factors and their impact on the local immune response. Toxin gene profiles were generated from 188 S. aureus isolated as single infecting organisms from skin lesions and demonstrated a higher potential to express ETA, ETB, and PVL than community isolates (p
- Published
- 2013