1. Monocyte subsets study in children with Mycoplasma pneumoniae pneumonia
- Author
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Lei Yang, Zhihua Wang, Yushui Wang, Yan Liu, and Jing Ye
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Allergy ,Adolescent ,CD14 ,Immunology ,Lipopolysaccharide Receptors ,Disease ,Gastroenterology ,Monocytes ,Flow cytometry ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Pneumonia, Mycoplasma ,medicine ,Humans ,Child ,030203 arthritis & rheumatology ,Monocyte subsets ,medicine.diagnostic_test ,business.industry ,Monocyte ,Receptors, IgG ,HLA-DR Antigens ,Flow Cytometry ,medicine.disease ,Mycoplasma pneumoniae ,Pneumonia ,030104 developmental biology ,medicine.anatomical_structure ,Child, Preschool ,Female ,business ,Biomarkers - Abstract
The aim of this study was to evaluate the changes in the three subsets of monocyte (classical, intermediate, and non-classical) and the expression of human leukocyte antigen-DR (HLA-DR) on monocyte subsets during MP pneumonia in children. Monocyte subsets were analyzed in the peripheral blood of healthy volunteers and MP pneumonia patients at the stages of admission and remission after clinical therapy. They were defined as classical (CD14+CD16−), intermediate (CD14brightCD16+), and non-classical (CD14dimCD16+) using flow cytometry. Furthermore, three subsets of monocyte were analyzed for the expression of HLA-DR. Patients with MP pneumonia at admission had a higher proportion of intermediate and non-classical monocytes than healthy subjects (all P
- Published
- 2019
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