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Your search keyword '"Yao, Shifei"' showing total 3 results
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3 results on '"Yao, Shifei"'

2. CD5L attenuates allergic airway inflammation by expanding CD11chigh alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2.

Author

Weng, Danlin, Gao, Song, Shen, Hailan, Yao, Shifei, Huang, Qi, Zhang, Yanyu, Huang, Wenjie, Wang, Yan, Zhang, Xuemei, Yin, Yibing, and Xu, Wenchun

Subjects
ALVEOLAR macrophages, NLRP3 protein, INFLAMMASOMES, HOUSE dust mites
Abstract

Allergic asthma is an airway inflammatory disease dominated by type 2 immune responses and there is currently no curative therapy for asthma. CD5‐like antigen (CD5L) has been known to be involved in a variety of inflammatory diseases. However, the role of CD5L in allergic asthma remains unclear. In the present study, mice were treated with recombinant CD5L (rCD5L) during house dust mite (HDM) and ovalbumin (OVA) challenge to determine the role of CD5L in allergic asthma, and the underlying mechanism was further explored. Compared with PBS group, serum CD5L levels of asthmatic mice were significantly decreased, and the levels of CD5L in lung tissues and bronchoalveolar lavage fluid (BALF) were significantly increased. CD5L reduced airway inflammation and Th2 immune responses in asthmatic mice. CD5L exerted its anti‐inflammatory function by increasing CD11chigh alveolar macrophages (CD11chigh AMs), and the anti‐inflammatory role of CD11chigh AMs in allergic asthma was confirmed by CD11chigh AMs depletion and transfer assays. In addition, CD5L increased the CD5L+ macrophages and inhibited NLRP3 inflammasome activation by increasing HDAC2 expression in lung tissues of asthmatic mice. Hence, our study implicates that CD5L has potential usefulness for asthma treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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3. CD5L attenuates allergic airway inflammation by expanding CD11c high alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2.

Author

Weng D, Gao S, Shen H, Yao S, Huang Q, Zhang Y, Huang W, Wang Y, Zhang X, Yin Y, and Xu W

Subjects
Animals, Apoptosis Regulatory Proteins metabolism, Bronchoalveolar Lavage Fluid, CD11c Antigen metabolism, Disease Models, Animal, Histone Deacetylase 2, Inflammasomes metabolism, Inflammation, Lung, Mice, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, Ovalbumin, Receptors, Scavenger metabolism, Asthma, Macrophages, Alveolar
Abstract

Allergic asthma is an airway inflammatory disease dominated by type 2 immune responses and there is currently no curative therapy for asthma. CD5-like antigen (CD5L) has been known to be involved in a variety of inflammatory diseases. However, the role of CD5L in allergic asthma remains unclear. In the present study, mice were treated with recombinant CD5L (rCD5L) during house dust mite (HDM) and ovalbumin (OVA) challenge to determine the role of CD5L in allergic asthma, and the underlying mechanism was further explored. Compared with PBS group, serum CD5L levels of asthmatic mice were significantly decreased, and the levels of CD5L in lung tissues and bronchoalveolar lavage fluid (BALF) were significantly increased. CD5L reduced airway inflammation and Th2 immune responses in asthmatic mice. CD5L exerted its anti-inflammatory function by increasing CD11c high alveolar macrophages (CD11c high AMs), and the anti-inflammatory role of CD11c high AMs in allergic asthma was confirmed by CD11c high AMs depletion and transfer assays. In addition, CD5L increased the CD5L + macrophages and inhibited NLRP3 inflammasome activation by increasing HDAC2 expression in lung tissues of asthmatic mice. Hence, our study implicates that CD5L has potential usefulness for asthma treatment., (© 2022 The Authors. Immunology published by John Wiley & Sons Ltd.)

Published
2022
Full Text
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