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Your search keyword '"Chen, Xiangjie"' showing total 5 results
Start Over Author "Chen, Xiangjie" Journal immunology
5 results on '"Chen, Xiangjie"'

1. Ceftazidime reduces cellular Skp2 to promote type‐I interferon activity

Author

Qiao, Caixia, primary, Huang, Fan, additional, He, Jiuyi, additional, Wu, Qiuyu, additional, Zheng, Zhijin, additional, Zhang, Tingting, additional, Miao, Ying, additional, Yuan, Yukang, additional, Chen, Xiangjie, additional, Du, Qian, additional, Xu, Yang, additional, Wu, Depei, additional, Yu, Zhengyuan, additional, and Zheng, Hui, additional

Published
2023
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2. E3 ubiquitin ligase MID1 ubiquitinates and degrades type‐I interferon receptor 2

Author

Chen, Xiangjie, primary, Zhao, Qian, additional, Xu, Ying, additional, Wu, Qiuyu, additional, Zhang, Renxia, additional, Du, Qian, additional, Miao, Ying, additional, Zuo, Yibo, additional, Zhang, Hong‐Guang, additional, Huang, Fan, additional, Ren, Tengfei, additional, He, Jiuyi, additional, Qiao, Caixia, additional, Li, Yue, additional, Li, Shifeng, additional, Xu, Yang, additional, Wu, Depei, additional, Yu, Zhengyuan, additional, Lv, Haitao, additional, Wang, Jun, additional, Zheng, Hui, additional, and Yuan, Yukang, additional

Published
2022
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3. Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3

Author

Chen, Xiangjie, primary, Xu, Ying, additional, Tu, Wenhui, additional, Huang, Fan, additional, Zuo, Yibo, additional, Zhang, Hong‐Guang, additional, Jin, Lincong, additional, Feng, Qian, additional, Ren, Tengfei, additional, He, Jiuyi, additional, Miao, Ying, additional, Yuan, Yukang, additional, Zhao, Qian, additional, Liu, Jiapeng, additional, Zhang, Renxia, additional, Zhu, Li, additional, Qian, Feng, additional, Zhu, Chuanwu, additional, Zheng, Hui, additional, and Wang, Jun, additional

Published
2021
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4. Small‐molecule inhibitors of ubiquitin‐specific protease 7 enhance type‐I interferon antiviral efficacy by destabilizing SOCS1

Author

Yuan, Yukang, primary, Miao, Ying, additional, Zeng, Chenhua, additional, Liu, Jin, additional, Chen, Xiangjie, additional, Qian, Liping, additional, Wang, Xiaofang, additional, Qian, Feng, additional, Yu, Zhengyuan, additional, Wang, Jun, additional, Qian, Guanghui, additional, Fu, Qian, additional, Lv, Haitao, additional, and Zheng, Hui, additional

Published
2019
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5. Small‐molecule inhibitors of ubiquitin‐specific protease 7 enhance type‐I interferon antiviral efficacy by destabilizing SOCS1.

Author

Yuan, Yukang, Miao, Ying, Zeng, Chenhua, Liu, Jin, Chen, Xiangjie, Qian, Liping, Wang, Xiaofang, Qian, Feng, Yu, Zhengyuan, Wang, Jun, Qian, Guanghui, Fu, Qian, Lv, Haitao, and Zheng, Hui

Subjects
TYPE I interferons, SUPPRESSORS of cytokine signaling, PROTEASE inhibitors, ANTIVIRAL agents, PROTEIN stability
Abstract

Summary: Type‐I interferons (IFN‐I) are used as common antiviral drugs for a range of viral diseases in clinic. However, the antiviral efficacy of IFN‐I is largely restricted by negative regulators of IFN‐I signaling in cells. Therefore, identification of intracellular inhibitors of IFN‐I signaling is important for developing novel targets to improve IFN‐I antiviral therapy. In this study, we report that the deubiquitinase ubiquitin‐specific protease 7 (USP7) negatively regulates IFN‐I‐mediated antiviral activity. USP7 physically interacts with suppressor of cytokine signaling 1 (SOCS1) and enhances SOCS1 protein stability by deubiquitination effects, which in turn restricts IFN‐I‐induced activation of Janus kinase–signal transducer and activator of transcription 1 signaling. Interestingly, viral infection up‐regulates USP7 and therefore facilitates viral immune evasion. Importantly, the USP7 small‐molecule inhibitors P5091 and P22077 inhibit SOCS1 expression and enhance IFN‐I antiviral efficacy. Our findings identify a novel regulator of IFN‐I antiviral activity and reveal that USP7 inhibitors could be potential enhancement agents for improving IFN‐I antiviral therapy. [ABSTRACT FROM AUTHOR]

Published
2020
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