1. Human monoclonal Fab and human plasma antibodies to carbamyl-epitopes cross-react with malondialdehyde-adducts
- Author
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Piotr Prus, S. Pauliina Turunen, Jaakko Lehtimäki, Chunguang Wang, Sohvi Hörkkö, Marja Veneskoski, and Outi Kummu
- Subjects
Phage display ,T-Lymphocytes ,Immunology ,Apoptosis ,Acetaldehyde ,Cross Reactions ,Binding, Competitive ,Epitope ,Epitopes ,Immunoglobulin Fab Fragments ,Jurkat Cells ,Mice ,chemistry.chemical_compound ,Malondialdehyde ,Animals ,Humans ,Immunology and Allergy ,Autoantibodies ,biology ,Macrophages ,Antibodies, Monoclonal ,Original Articles ,Atherosclerosis ,Immunity, Humoral ,Lipoproteins, LDL ,Disease Models, Animal ,chemistry ,Biochemistry ,Low-density lipoprotein ,Monoclonal ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Antibody ,Cell Surface Display Techniques ,Clone (B-cell biology) ,Oxidation-Reduction ,Lipoprotein - Abstract
Summary Oxidized low-density lipoprotein (OxLDL) plays a crucial role in the development of atherosclerosis. Carbamylated LDL has been suggested to promote atherogenesis in patients with chronic kidney disease. Here we observed that plasma IgG and IgM antibodies to carbamylated epitopes were associated with IgG and IgM antibodies to oxidation-specific epitopes (ρ = 0·65–0·86, P
- Published
- 2014
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