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Start Over Author "Pali-Schöll, I" Journal immunology letters
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3. The ABC of clinical and experimental adjuvants--a brief overview.

Author

Brunner R, Jensen-Jarolim E, and Pali-Schöll I

Subjects
Adjuvants, Immunologic pharmacology, Aluminum Compounds immunology, Animals, Flagellin immunology, Freund's Adjuvant immunology, Humans, Lipid A analogs & derivatives, Lipid A immunology, Nanoparticles, Polysorbates, Squalene immunology, Adjuvants, Immunologic therapeutic use, Aluminum Compounds therapeutic use, Bacterial Toxins immunology, Vaccines, Virosomes immunology
Abstract

Adjuvants are compounds that can increase and/or modulate the intrinsic immunogenicity of an antigen and elicit strong and long lasting immune responses. During the last 80 years many adjuvants have been used in experimental settings, but due to various shortcomings of most of them only aluminum compounds made it into regular clinical usage. However, during the last years promising candidates have arisen that may finally adjunct or displace aluminum substances as main adjuvant. This review summarizes information on adjuvants currently used in clinical as well as in experimental settings.

Published
2010
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