1. Remission of Psoriasis in a Patient with Hepatocellular Carcinoma Treated with Sorafenib
- Author
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Efstathios A, Antoniou, Ioannis, Koutsounas, Christos, Damaskos, and Sotiris, Koutsounas
- Subjects
Keratinocytes ,Male ,Niacinamide ,Vascular Endothelial Growth Factor A ,Carcinoma, Hepatocellular ,Vascular Endothelial Growth Factor Receptor-1 ,Phenylurea Compounds ,Liver Neoplasms ,Remission Induction ,Hepacivirus ,Sorafenib ,Hepatitis C ,Humans ,Psoriasis ,Protein Kinase Inhibitors ,Aged ,Cell Proliferation - Abstract
Psoriasis is a chronic, immune-mediated and angiogenesis-dependent disease. Activated keratinocytes in psoriatic lesions produce pro-angiogenic cytokines, including vascular endothelial growth factor (VEGF), which binds to vascular endothelial growth factor receptor (VEGFR) and promotes cell proliferation and angiogenesis. Sorafenib (BAY 43-9006) is a molecular multikinase inhibitor of RAF kinase, platelet-derived growth factor (PDGF), VEGFR-1, -2, -3, platelet-derived growth factor receptor (PDGFR)-β and c-Kit. This molecule inhibits tumor cell proliferation and angiogenesis and it is currently approved for the treatment of hepatocellular carcinoma (HCC).We present the complete remission of resistant psoriasis in a hepatitis C virus (HCV)-infected cirrhotic patient who was treated with sorafenib, for recurrent HCC.Several targeted therapies have demonstrated efficacy against psoriasis. More research and well-designed studies, both in novel drugs and those already marketed for other indications, are needed to determine their value as potential novel therapies for psoriasis.
- Published
- 2016