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Start Over Author "Rodriguez-paradisi, E." Journal in vivo athens greece
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1. Tumor cells cultured in vivo in diffusion chambers induce hematological alterations.

Author

Diament M, Klein S, Rodriguez Paradisi E, Elia ID, and De Bonaparte YP

Subjects
Animals, Bone Marrow Cells, Cell Adhesion physiology, Cell Division physiology, Diffusion Chambers, Culture, Female, Leukocyte Count, Male, Mice, Mice, Inbred BALB C, Tumor Cells, Cultured cytology, Adenoma, Granulocytes cytology, Mammary Neoplasms, Animal
Abstract

We have studied in BALB/c mice the hematological alterations of the host induced by the growth of tumor cells in diffusion chambers (DC) In this model, host-tumor interactions are only mediated by soluble factors. Tumor cells proliferate and grow in DC up to 15 days after implant. Our results show a reversal of the granulocyte-lymphocyte ratio in peripheral blood, with lymphopenia and a relative increase of myeloid progenitors in the bone marrow of mice bearing DC with M3 tumor cells (M3TC).

Published
1995

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