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Co-administration of prescribed drug with that of over the counter products may either lead to altered therapeutic effect, adverse effects or depleted efficacy of one or both drugs. One such example is geriatric patients being treated with ayurvedic cardioprotectives formulations for ischemia generally suffer from bowel movement discomfort and tend to consume herbal laxatives simultaneously without physician's consent. The proposed study was undertaken to determine whether any interaction exists when Arjuna, a cardioprotective agent is concomitantly administered orally with Haritaki churna, a laxative agent, in isoproterenol (subcutaneous administration) induced ischemic rats on pharmacodynamic level. Data was statistically evaluated by comparing the effect of combination group with that of isoproterenol control and Arjuna group on electrocardiogram (ECG) patterns, blood serum parameters, gastric motility using ONE WAY ANNOVA, p < 0.05 followed by Tukey's multiple comparison test. Results suggests that there is significant decrease in cardioprotective efficacy of Arjuna when administered together with Haritaki. [ABSTRACT FROM AUTHOR]

As cancer continues to be one of the biggest threats worldwide and causes maximum deaths after cardiovascular diseases, a greater emphasis must be given for newer strategies for the development of anti-cancer drugs. Cancer treatment strategies target various mechanisms such as apoptosis, metastasis, angiogenesis, etc. Angiogenesis, which is the process of generation of new capillary blood vessels, can be an excellent target for anti-cancer therapy, as a tumor cannot grow further without it. The present study aims to evaluate and compare anti-angiogenic activity of ethanolic extract of Parkia biglandulosa (EEPB) and its isolate β-sitosterol by regenerative angiogenesis assay using caudal fin of adult zebrafish. One of its active constituents that is β-sitosterol, which was expected to show anti-cancer activity, was isolated by using flash chromatography and its activity was checked along with crude ethanolic extract of Parkia biglandulosa (EEPB). Results of regenerative angiogenesis compared by one way ANOVA followed by Tukey's test showed significant inhibition of fin growth when compared with control group which signified anti-angiogenic effect of test compounds. [ABSTRACT FROM AUTHOR]