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Keywords: Autosomal recessive inheritance; best's disease; macular hole EN Autosomal recessive inheritance best's disease macular hole 1173 1175 3 06/02/20 20200601 NES 200601 A 22-year-old male was evaluated for both eye poor vision. Fundus examination of both eyes showed bilateral subretinal yellow deposits extending up to arcades [Figure 1]a and [Figure 1]b with macular hole in right eye and subretinal fibrosis in left eye [Figure 1]c and [Figure 1]d. Electroretinogram (ERG) was near normal in both eyes [Figure 2] and electrooculogram (EOG) showed light-peak absence [Figure 3]. [Extracted from the article]

Best′s vitelliform macular dystrophy is a hereditary form of progressive macular dystrophy that can be complicated by choroidal neovascularization. Authors report successful treatment of choroidal neovascularization with intravitreal bevacizumab in one such eye in an ′adult′ Indian male with visual improvement. A 23-year-old male presented with diminution of vision in the right eye for the past sixteen months. Visual acuity was 20/400 in the that eye. After three consecutive intravitreal injections of bevacizumab (1.25 mg/0.05 ml), vision improved to 20/120. Seven months following the last injection of bevacizumab, fundus appeared stable and visual acuity was maintained. No drug-related ocular or systemic side effects were encountered. To the best of our knowledge (PubMed search), this is the first report of its kind in an adult Indian patient. Intravitreal bevacizumab appears to be a promising and cost-effective modality of treatment in such eyes with potential for improvement in vision. However, a long-term follow-up is warranted.