38 results on '"Mukherjee B"'
Search Results
2. An unusual case of intraorbital foreign body and its management
- Author
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Mukherjee Bipasha, Goel Shubhra, and Subramanian Nirmala
- Subjects
Orbital foreign body ,plastic ,thermal injury ,Ophthalmology ,RE1-994 - Abstract
Intraorbital foreign bodies are usually the result of accidental trauma and can lead to considerable morbidity. We report an unusual case of an industrial injury in a plastic manufacuring unit wherein hot molten plastic splashed and solidified inside the orbit. The resultant increased intraorbital pressure led to loss of vision in that eye. The extreme temperature of the foreign body caused extensive thermal damage to the surrounding adnexal structures. Staged reconstructive surgery was undertaken to repair the damage, with an acceptable final cosmetic outcome. Employment of protective eye wear to prevent such accidents in high-risk occupations should be made mandatory.
- Published
- 2011
3. Blow-in fracture of the orbital roof presenting as a case of non-resolving choroidal effusion
- Author
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Mukherjee Bipasha and Bhende Muna
- Subjects
Blow-in fracture ,choroidal effusion ,ultrasonography ,Ophthalmology ,RE1-994 - Abstract
A 34-year-old male patient was referred to us as a case of non-resolving suprachoroidal hemorrhage. History revealed decrease in right eye vision following trauma to forehead. B scan ultrasonography (USG) of the right eye showed a high-reflective structure indenting the globe. It turned out to be an inferiorly displaced fracture fragment from the orbital roof on computerized tomography (CT) scan. The choroidal elevation disappeared after open reduction of the fracture fragment and patient had good recovery of vision. USG and CT scan were helpful in the diagnosis and management of this case.
- Published
- 2010
4. Panophthalmitis due to Aspergillus in an acquired immunodeficiency syndrome patient: Clinicopathological study of a case
- Author
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Biswas Jyotirmay, Singh Chekitaan, Mukherjee Bipasha, and Rama Kumar GVN
- Subjects
Ophthalmology ,RE1-994 - Published
- 2007
5. Association of fracture type with enophthalmos and intraorbital volume correction in orbital fractures: A computed tomographic study.
- Author
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Parameswaran A, Panneerselvam E, and Mukherjee B
- Abstract
Purpose: To determine the influence of different types of orbital fractures on the radiographic post-treatment outcomes., Methods: The investigation was a retrospective cohort study involving CT data of all patients who underwent delayed primary or secondary surgery for orbital/zygomatico-orbital trauma between 2019 and 2021. The sample was divided into three groups 1, 2, and 3: isolated floor, floor and medial wall, and combined orbit and zygomatic complex fractures. The type of orbital fracture was the exposure, while the outcome measures were reduction in enophthalmos and intraorbital volume and linear relationship between the two variables. Data were analyzed for variance between groups and association. Statistical significance was set at < 0.05., Results: Forty-four patients (3 females and 41 males) with a mean age of 28.6 years were included in the study. Reductions in enophthalmos (P < 0.001) and intraorbital volume (P = 0.003) demonstrated significant variance between the groups. For every cubic centimeter of reduction in volume, the reduction in enophthalmos was 0.78 mm (P < 0.001) in isolated floor fractures, 0.60 mm (P = 0.013) in combined fractures involving the floor and medial walls, and 0.24 mm (P = 0.456) in combined fractures of the orbit and zygoma., Conclusion: Correction of enophthalmos strongly depends on the type of orbital fracture. There exists a significant linear relationship between enophthalmos and intraorbital volume in fractures involving the internal orbit., (Copyright © 2024 Copyright: © 2024 Indian Journal of Ophthalmology.)
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- 2024
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6. Clinical spectrum and clinicopathological correlation of pediatric orbital tumors: 20 years' experience from a tertiary eye care center.
- Author
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Vijay V, Alam MS, Subramanian N, Krishnakumar S, Biswas J, and Mukherjee B
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- Male, Female, Child, Humans, Retrospective Studies, Biopsy, Tertiary Care Centers, Orbital Neoplasms diagnosis, Orbital Neoplasms epidemiology, Orbital Neoplasms pathology, Rhabdomyosarcoma diagnosis, Rhabdomyosarcoma epidemiology
- Abstract
Purpose: To study the epidemiological profile of various pediatric orbital tumors and determine their clinicopathological correlation over 20 years., Methods: A retrospective analysis of all pediatric patients with orbital tumors from the medical records between 1995 and 2015 was done. Tumors were categorized based on their cellular origin. Demographic details, clinical and histopathological diagnoses, frequency, and clinicopathological correlation were studied., Results: A total of 265 pediatric patients with orbital tumors were analyzed, of which 145 (54.7%) patients were males and 120 (45.3%) were females. The mean age was 7 years (median: 6 years; range: 10 days-16 years). The distribution of lesions in each group was as follows: vasculogenic, 76 (28.7%); lipogenic and myxoid, 66 (25%); myogenic, 31 (11.7%); optic nerve and meningeal, 22 (8.3%); lymphoid and lymphoproliferative, 18 (6.8%); secondary orbital tumors, 14 (5.2%); histiocytic, 9 (3.4%); miscellaneous, 9 (3.4%), lacrimal gland, 8 (3%); mesenchymal with neural differentiation, 6 (2%); osseous, 4 (1.5%), and fibrocystic, 2 (0.8%). The most common benign and malignant pediatric orbital tumors were dermoid cysts (65, 24.5%) and rhabdomyosarcoma (31, 11.7%). A statistically significant ( P < 0.0001) clinicopathological correlation was observed in 208 (83.2%) out of 250 biopsy-proven cases., Conclusion: Pediatric orbital neoplasms include a broad spectrum of benign and malignant lesions. Vasculogenic tumors constitute the majority of them, followed by lipogenic and myxoid tumors. A thorough knowledge of the incidence, clinical profile, imaging features, and histopathology of specific orbital tumors aids in accurate diagnosis and their successful management., (Copyright © 2023 Copyright: © 2023 Indian Journal of Ophthalmology.)
- Published
- 2024
- Full Text
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7. Dysthyroid optic neuropathy: Demographics, risk factors, investigations, and management outcomes.
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Poonam NS, Alam MS, Oberoi P, and Mukherjee B
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- Humans, Male, Evoked Potentials, Visual, Retrospective Studies, Risk Factors, Demography, Optic Nerve Diseases diagnosis, Optic Nerve Diseases epidemiology, Optic Nerve Diseases therapy, Hyperthyroidism complications, Hyperthyroidism diagnosis, Hyperthyroidism epidemiology
- Abstract
Purpose: To analyze the clinical presentations, risk factors, and management outcomes in patients presenting with dysthyroid optic neuropathy (DON)., Methods: This is a retrospective, single-center study carried out on consecutive patients presenting with DON over a period of 4 years (2013-2016). The VISA classification was used at the first visit and subsequent follow-ups. The diagnosis was based on optic nerve function tests and imaging features. Demographic profiles, clinical features, risk factors, and management outcomes were analyzed., Results: Thirty-seven eyes of 26 patients diagnosed with DON were included in the study. A significant male preponderance was noted (20, 76.92%). Twenty patients (76.9%, P = 0.011) had hyperthyroidism, and 15 (57.69%, P = 0.02) were smokers. Decreased visual acuity was noted in 28 eyes (75.6%). Abnormal color vision and relative afferent pupillary defects were seen in 24 (64.86%) eyes, and visual field defects were seen in 30 (81.01%) eyes. The visual evoked potential (VEP) showed a reduced amplitude in 30 (96.77%, P = 0.001) of 31 eyes and delayed latency in 20 (64.51%, P = 0.0289) eyes. Twenty-six (70.27%) patients were treated with intravenous methyl prednisolone (IVMP) alone, whereas 11 (29.72%) needed surgical decompression. The overall best-corrected visual acuity improved by 0.2 l logMARunits. There was no statistically significant difference in outcome between medically and surgically treated groups. Four patients developed recurrent DON, and all of them were diabetics., Conclusion: Male gender, hyperthyroid state, and smoking are risk factors for developing DON. VEP, apical crowding, and optic nerve compression are sensitive indicators for diagnosing DON. Diabetics may have a more defiant course and are prone to develop recurrent DON., Competing Interests: None
- Published
- 2022
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8. The spectrum and clinicopathological correlation of eyelid lesions: Twenty years' experience at a tertiary eye care center in South India.
- Author
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Banerjee P, Koka K, Alam MS, Subramanian N, Biswas J, Krishnakumar S, and Mukherjee B
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- Adult, Eyelids, Humans, Middle Aged, Retrospective Studies, Young Adult, Eyelid Neoplasms diagnosis, Eyelid Neoplasms epidemiology, Sebaceous Gland Neoplasms, Skin Neoplasms
- Abstract
Purpose: : To study the epidemiological pattern and diagnostic accuracy of histopathologically proven eyelid lesions over a period of two decades., Methods: : A retrospective study of all histopathologically proven eyelid lesions from April 1996 to March 2016 was conducted. The lesions were broadly categorized as benign or malignant. Inflammatory and infectious lesions were included under the benign category. The percentage and diagnostic accuracy of each lesion was calculated., Results: : There were a total of 994 (M = 551, F = 443) cases. The mean age of the patients was 43.5 ± 19.9 years. There were 809 (81.4%) benign and 185 (18.6%) malignant lesions. Benign lesions were commonly seen in the fourth decade, while the malignant ones in the late fifth decade. The upper lid was the most common site in both groups (n = 481, 48.4%). The commonest benign lesion was chalazion (n = 484, 59.8%). Dermal nevus (n = 94, 11.6%) was the most common benign neoplasm, while Molluscum contagiosum (n = 25, 3.09%) was the most common infectious lesion. Sebaceous gland carcinoma (SGC) (n = 103, 55.7%) was the leading malignant lesion followed by basal cell carcinoma (n = 39, 21.1%). Eleven malignant cases were misdiagnosed as benign (5.9%). Chalazion (99.1%) and SGC (65%) had the highest diagnostic accuracy, while Molluscum (40%) and squamous cell carcinoma (40%) were the most misdiagnosed lesions in the respective groups., Conclusion: : Benign eyelid lesions are far more common than malignant ones. Atypical and rare presentations may lead to misdiagnosis. Knowledge of epidemiological patterns and clinical features can help in achieving higher diagnostic accuracy., Competing Interests: None
- Published
- 2022
- Full Text
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9. Role of pre-operative percutaneous embolization in orbital alveolar soft part sarcoma - An experience from a tertiary eye-care center.
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Koka K, Singh P, Nisar SP, Alam MS, Backiavathy V, Scott JX, Krishnakumar S, and Mukherjee B
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- Adolescent, Adult, Child, Child, Preschool, Humans, Male, Neoplasm Recurrence, Local, Retrospective Studies, Young Adult, Exophthalmos, Orbital Neoplasms diagnosis, Orbital Neoplasms therapy, Sarcoma, Alveolar Soft Part diagnosis, Sarcoma, Alveolar Soft Part therapy
- Abstract
Purpose: To describe the clinic-radiological, pathological profile, and management outcomes of primary alveolar soft-part sarcoma (ASPS) of the orbit., Methods: A retrospective analysis of all histopathologically proven cases of orbital ASPS that presented between May 2016 and September 2019 was done. Data collected included demographics, clinical features, imaging characteristics, metastatic workup, management, and follow-up., Results: Five patients, of which four were males, presented to us during the study period. The mean age of presentation was 12.6 years (range 3-22 years). The most common presenting features were abaxial proptosis (n = 4) and diminished vision (n = 4). Imaging showed a well-defined orbital mass in all patients with internal flow voids in three. Preoperative percutaneous embolization with cyanoacrylate glue was done in these three patients owing to high vascularity. Four patients underwent complete tumor excision. One patient underwent exenteration. Histopathology showed polygonal tumor cells arranged in a pseudo-alveolar pattern and Periodic Acid-Schiff (PAS) positive crystals in the cytoplasm in all patients. One patient had systemic metastasis at presentation and developed a local recurrence after 3 months. No recurrence or metastasis was noted in the remaining four patients at a mean final follow-up of 11.2 months (range 5-15 months)., Conclusion: ASPS is a rare orbital neoplasm that poses a diagnostic and therapeutic challenge. Imaging might show a soft-tissue tumor with high vascularity. Multidisciplinary management with interventional radiologists for preoperative embolization of vascular lesions helps minimize intraoperative bleeding and aids in complete tumor resection. A localized orbital disease carries a better prognosis., Competing Interests: None
- Published
- 2021
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10. An objective technique to calculate dermis-fat graft volume.
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Mukherjee B
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- Dermis, Eye, Artificial, Humans, Orbit surgery, Anophthalmos, Orbital Implants
- Abstract
We describe an objective method to measure the volume of a dermis-fat graft (DFG) implant for socket reconstruction. We reviewed the charts of 10 patients undergoing dermis fat grafting as a primary or secondary implant for anophthalmic socket reconstruction between January 2018 and December 2019. The amount of the DFG required to replace the volume of an appropriate spherical implant for the operated eye was predetermined. The volume of the DFG implant was measured by the water displacement method as per the Archimedes principle. Patient demographics, complications, and the outcome were analyzed regarding cosmesis and volume replacement. All patients were satisfied with the final cosmesis. Follow-up ranged from 6 to 18 months (mean 10.7 months). Thus, we concluded that the water displacement method is a simple and easy procedure to objectively determine the amount of the autologous DFG needed to replace the volume in an anophthalmic socket., Competing Interests: None
- Published
- 2021
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11. Orbital and adnexal amyloidosis: Thirty years experience at a tertiary eye care center.
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Banerjee P, Alam MS, Subramanian N, Kundu D, Koka K, Poonam NS, and Mukherjee B
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- Adult, Female, Humans, Male, Middle Aged, Retrospective Studies, Amyloidosis diagnosis, Amyloidosis epidemiology, Amyloidosis therapy, Blepharoptosis diagnosis, Blepharoptosis epidemiology, Blepharoptosis etiology, Conjunctival Diseases, Orbital Diseases diagnosis, Orbital Diseases epidemiology, Orbital Diseases therapy
- Abstract
Purpose: The aim of this work was to study the clinical presentation, management and outcomes of orbital and adnexal amyloidosis., Methods: This retrospective analysis included all the patients diagnosed with orbital and adnexal amyloidosis between January 1990 and December 2019. Positive staining with Congo Red and apple-green birefringence on polarized light microscopy established the diagnosis. Data analyzed included demographic profile, varied presentations, management, and outcome., Results: Thirty-three eyes of 26 patients were included. The male:female ratio was 1:1. The mean age of the study population was 42.6 ± 16 years. The median duration of symptoms was two years. Unilateral involvement was seen in 19 eyes (right = 11, left = 8). The most common presenting feature was acquired ptosis. Eyelid was the most commonly affected site followed by orbit and conjunctiva. Two patients had systemic involvement in the form of multiple myeloma and lymphoplasmacytic lymphoma. Complete excision was done in seven (26.9%) cases while 19 (73.1%) cases underwent debulking. Three patients underwent ptosis surgery. The median duration of follow-up was 1.5 years. Three cases had recurrence and underwent repeat surgery., Conclusion: Orbit and adnexa is a rare site for amyloidosis. It is usually localized; however it can occur as a part of systemic amyloidosis. Eyelid is the most common site of involvement and patients usually present as eyelid mass or ptosis. Complete excision is difficult and most of the patients usually undergo debulking surgery. All patients should undergo screening for systemic amyloidosis., Competing Interests: None
- Published
- 2021
- Full Text
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12. Role of neuroimaging in cases of primary and secondary hemifacial spasm.
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Banerjee P, Alam MS, Koka K, Pherwani R, Noronha OV, and Mukherjee B
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- Adult, Female, Humans, Male, Middle Aged, Neuroimaging, Retrospective Studies, Hemifacial Spasm diagnosis, Hemifacial Spasm epidemiology
- Abstract
Purpose: The objective of this study was to analyze the role of neuroimaging and documenting various intracranial pathologies in primary and secondary hemifacial spasm., Methods: This retrospective study included patients with HFS who had undergone neuroimaging. The demographic profile, onset, progression, neuroimaging findings, and types of HFS were documented and analyzed., Results: A total of 202 patients (male = 110, female = 92) were included. The mean age of the study population was 51.81 ± 11.76 years. The right side was involved in 104 patients, the left side was involved in 97 patients and bilateral involvement was observed in one patient. Primary HFS: secondary HFS was 9.6:1. The mean age of onset of the spasms in the primary HFS group was 49.26 ± 8.35 years and in secondary HFS was 43.13 ± 12.12 years respectively. The anterior inferior cerebellar artery was the major vessel causing neurovascular conflict in primary HFS (n = 55). Facial nerve palsy was the most common cause (n = 13) of secondary HFS followed by cerebellopontine angle (CPA) tumors., Conclusion: The hemifacial spasm occurs mostly in the fifth decade of life. Primary HFS is more prevalent than secondary HFS. Clinical distinction between them is difficult. Neuroimaging is essential to detect the conflicting vasculature in cases of primary HFS and pathologies like CPA tumor, cyst, and aneurysms in cases of secondary HFS., Competing Interests: None
- Published
- 2021
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13. Commentary: Thyroid eye disease in India: A wake-up call?
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Mukherjee B
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- Humans, India epidemiology, Internet, Surveys and Questionnaires, Graves Ophthalmopathy diagnosis, Graves Ophthalmopathy epidemiology
- Abstract
Competing Interests: None
- Published
- 2020
- Full Text
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14. Clinical spectrum and management outcomes of Langerhans cell histiocytosis of the orbit.
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Koka K, Alam MS, Subramanian N, Subramanian K, Biswas J, and Mukherjee B
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- Adult, Child, Humans, India, Infant, Orbit, Retrospective Studies, Histiocytosis, Langerhans-Cell diagnosis, Histiocytosis, Langerhans-Cell therapy, Orbital Diseases diagnosis, Orbital Diseases therapy
- Abstract
Purpose: To describe the clinical spectrum and management outcomes of Langerhans cell histiocytosis (LCH) involving the orbit., Methods: Retrospective review of patients with orbital LCH presenting at the Sankara Nethralaya, Chennai, India, over the past 15 years. Demographic details, presenting features, radiology, histopathology, immunohistochemistry, and management outcomes were analyzed., Results: Nine patients were reviewed. The mean age of presentation was 10.12 ± 14.31 years (range: 6 weeks to 35 years). Eyelid swelling was the most common presenting feature (4, 44.4%), followed by proptosis (3, 33.3%). The mean duration of the presentation was 2.21 ± 2.77 months. Radiological investigations revealed orbital roof osteolytic defects in six (66.6%) patients. Six patients underwent near-complete excision of the mass while three underwent incisional biopsy. Histopathology revealed histiocytes with nuclear grooving and numerous eosinophils characteristic of LCH. The cells were positive for CD1a and S 100 antigens. None of the patients had any systemic involvement. Three received systemic steroids and four received systemic chemotherapy. At a mean follow-up of 17.85 ± 23.46 months, all had complete remission without any signs of recurrence. One patient was lost to follow-up after near-complete excision while one adult patient with a mass in the intraconal space had no recurrence after near-complete excision., Conclusion: LCH is a rare disorder of the orbit that commonly occurs in children and should be considered a differential for osteolytic lesions involving the orbit. All patients should undergo a systemic evaluation to rule out multifocal disease. The treatment depends upon disease extent and risk factors., Competing Interests: None
- Published
- 2020
- Full Text
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15. All India Ophthalmological Society - Oculoplastics Association of India consensus statement on preferred practices in oculoplasty and lacrimal surgery during the COVID-19 pandemic.
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Ali MJ, Hegde R, Nair AG, Bajaj MS, Betharia SM, Bhattacharjee K, Chhabra AK, Das JK, Dudeja G, Grover AK, Honavar SG, Kim U, Mahesh L, Mukherjee B, Sethi A, Sharma M, and Singh U
- Subjects
- COVID-19, Humans, India, Risk Assessment, SARS-CoV-2, Societies, Medical, Surgery, Plastic organization & administration, Betacoronavirus, Blepharoplasty methods, Consensus, Coronavirus Infections epidemiology, Lacrimal Apparatus Diseases surgery, Ophthalmology organization & administration, Pandemics, Pneumonia, Viral epidemiology, Practice Patterns, Physicians' standards
- Abstract
Oculoplastic surgeries encompass both emergency surgeries for traumatic conditions and infectious disorders as well as elective aesthetic procedures. The COVID-19 pandemic has brought about a drastic change in this practice. Given the highly infectious nature of the disease as well as the global scarcity of medical resources; it is only prudent to treat only emergent conditions during the pandemic as we incorporate evidence-based screening and protective measures into our practices. This manuscript is a compilation of evidence-based guidelines for surgical procedures that oculoplastic surgeons can employ during the COVID-19 pandemic. These guidelines also serve as the basic framework upon which further recommendations may be based on in the future, as elective surgeries start being performed on a regular basis., Competing Interests: None
- Published
- 2020
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16. The rare phenomenon of Marcus-Gunn jaw winking without ptosis: Report of 14 cases and review of the literature.
- Author
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Alam MS, Nishanth S, Ramasubramanian S, Swaminathan M, and Mukherjee B
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- Blinking, Child, Female, Humans, Jaw Abnormalities, Male, Reflex, Abnormal, Retrospective Studies, Blepharoptosis diagnosis, Blepharoptosis epidemiology, Heart Defects, Congenital, Nervous System Diseases
- Abstract
Purpose: To report a rare case series of 14 patients of the Marcus-Gunn jaw-winking phenomenon (MGJWP) without ptosis., Methods: This was a retrospective noninterventional case series. The medical records of all patients diagnosed with MGJWP over the past 10 years were retrieved. Patients with documented evidence of absence of ptosis were segregated and analyzed for visual acuity, the severity of Marcus-Gunn, the presence of squint and amblyopia, and the presence of other aberrant regenerations., Results: A total of 207 patients were diagnosed with MGJWP, out of which 14 (6.76%) patients had isolated MGJWP without blepharoptosis. The mean age of presentation was 9.5 years and males and females were equally affected. The left eye was involved more commonly (57.2%) than the right eye. Twelve patients were congenital and two were presumed to be of traumatic origin. The most common refractive error in this cohort was astigmatism (10, 71.42%), followed by hyperopia (5, 35.71%). One patient had anisometropic amblyopia. Marcus-Gunn was found to be mild (≤2 mm of lid excursion) in all cases. None of the patients had strabismus or any other aberrant innervations. None of the patients underwent surgery and did not develop ptosis or worsening or improvement of Marcus-Gunn after a mean follow-up period of 2.3 years., Conclusion: Isolated MGJWP in the absence of ptosis is a very rare entity and this is the largest series to date to report such an occurrence. All patients had a mild form of MGJWP with no intervention required in any of the cases., Competing Interests: None
- Published
- 2020
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17. Burger sign: Ahmed glaucoma valves on magnetic resonance imaging.
- Author
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Mukherjee B, Shah D, Noronha OV, and Vijaya L
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- Humans, Intraocular Pressure, Magnetic Resonance Imaging, Postoperative Complications, Prosthesis Implantation, Treatment Outcome, Glaucoma diagnosis, Glaucoma surgery, Glaucoma Drainage Implants
- Abstract
Competing Interests: None
- Published
- 2020
- Full Text
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18. Solitary Fibrous Tumor of the lacrimal sac.
- Author
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Gudkar AI, Mukherjee B, and Krishnakumar S
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- Aged, Biomarkers, Tumor metabolism, Eye Neoplasms diagnostic imaging, Eye Neoplasms metabolism, Eye Neoplasms surgery, Female, Humans, Immunoenzyme Techniques, Lacrimal Apparatus Diseases diagnostic imaging, Lacrimal Apparatus Diseases metabolism, Lacrimal Apparatus Diseases surgery, Nasolacrimal Duct pathology, Nasolacrimal Duct surgery, Neoplasm Proteins metabolism, Ophthalmologic Surgical Procedures, Solitary Fibrous Tumors diagnostic imaging, Solitary Fibrous Tumors metabolism, Solitary Fibrous Tumors surgery, Tomography, X-Ray Computed, Eye Neoplasms pathology, Lacrimal Apparatus Diseases pathology, Solitary Fibrous Tumors pathology
- Abstract
Competing Interests: None
- Published
- 2019
- Full Text
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19. Cavernous hemangioma of the conjunctiva.
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Mukherjee B, Moosa S, and Rajagopal R
- Subjects
- Adolescent, Conjunctival Neoplasms surgery, Hemangioma, Cavernous surgery, Humans, Male, Ophthalmologic Surgical Procedures, Conjunctival Neoplasms pathology, Hemangioma, Cavernous pathology
- Abstract
Competing Interests: None
- Published
- 2019
- Full Text
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20. Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies.
- Author
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Alam MS, Tongbram A, Krishnakumar S, Biswas J, and Mukherjee B
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Conjunctival Neoplasms diagnosis, Eye Neoplasms diagnosis, Eyelid Neoplasms diagnosis, Frozen Sections, Lacrimal Apparatus Diseases diagnosis, Orbital Neoplasms diagnosis
- Abstract
Purpose: To analyze the diagnostic accuracy of frozen section in orbital and adnexal malignancies., Methods: A total of 55 cases between January 2006 and December 2011 for which intraoperative frozen section was performed for various orbital and adnexal lesions were included in the study. The frozen section diagnosis was compared with the permanent section diagnosis. Margin clearance was also compared between the two. Data were analysed using SPSS version 14. Odds ratio and cross-tabulation was used to perform the analysis., Results: The mean age at presentation was 51.46 ± 20 years. Eyelid was the most common site of involvement. Out of 55 cases, diagnosis was deferred in four cases (7.27%) on frozen section. Among 51 cases, 44 (86%) cases were concordant, whereas 7 (13%) cases were discordant. The sensitivity and specificity of frozen section compared to permanent section for diagnosis of malignancy was found to be 87.2% and 87.5%, respectively. The sensitivity and specificity of frozen section for diagnoses of basal cell carcinoma was found to be 100%, while it was 83.3% and 100% respectively for sebaceous gland carcinoma and 87.5% and 94.9% respectively for squamous cell carcinoma., Conclusion: Frozen section had high sensitivity and specificity when compared with permanent section for all three parameters studied. It is an important intraoperative tool that is increasingly being used in histopathological examination of ophthalmic lesions. However, it should not be used as a substitute for the permanent section and critical decisions based on it are best avoided., Competing Interests: None
- Published
- 2019
- Full Text
- View/download PDF
21. Ciliochoroidal melanoma presenting as bleeding anterior staphyloma: Report of a case and review of literature.
- Author
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Alam MS, Tongbram A, Krishnakumar S, and Mukherjee B
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- Adult, Biopsy, Choroid Neoplasms diagnosis, Choroid Neoplasms surgery, Eye Evisceration methods, Eye Hemorrhage diagnosis, Female, Humans, Melanoma diagnosis, Melanoma surgery, Scleral Diseases diagnosis, Scleral Diseases surgery, Choroid Neoplasms complications, Ciliary Body pathology, Eye Hemorrhage etiology, Melanoma complications, Scleral Diseases complications
- Abstract
Competing Interests: None
- Published
- 2019
- Full Text
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22. Necrotizing fungal infection due to Saksenaea erythrospora : A case report and review of literature.
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Mukherjee B and Kundu D
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- Biopsy, Child, Preschool, Eye Infections, Fungal microbiology, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Mucormycosis microbiology, Necrosis microbiology, Necrosis pathology, Eye Infections, Fungal diagnosis, Mucorales isolation & purification, Mucormycosis diagnosis
- Abstract
Mucormycosis caused by Saksenaea erythrospora is an emerging infection seen with soil contamination, burns and/or nosocomial infections. PCR amplification and internal transcribed spacer sequencing is gold standard for its identification. Here, we report a case of necrotizing fungal orbital infection by S. erythrospora in an immunocompetent child., Competing Interests: There are no conflicts of interest
- Published
- 2018
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23. Another brick in the wall.
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Mukherjee B and Salim S
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- Adult, Biomechanical Phenomena, Humans, Imaging, Three-Dimensional, Male, Orbital Fractures diagnosis, Tomography, X-Ray Computed, Fracture Fixation methods, Materials Testing methods, Orbital Fractures surgery, Polymethyl Methacrylate
- Abstract
Competing Interests: There are no conflicts of interest
- Published
- 2018
- Full Text
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24. Combined approach to management of periocular arteriovenous malformation by interventional radiology and surgical excision.
- Author
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Mukherjee B, Vijay V, and Halbe S
- Subjects
- Arteriovenous Malformations therapy, Child, Female, Humans, Magnetic Resonance Imaging, Orbit diagnostic imaging, Arteriovenous Malformations diagnosis, Embolization, Therapeutic methods, Ophthalmologic Surgical Procedures methods, Orbit blood supply, Radiology, Interventional methods, Tomography, X-Ray Computed methods
- Abstract
Periorbital arteriovenous malformations (AVMs) are congenital lesions that may cause significant morbidity such as amblyopia, cosmetic disfigurement, or chronic pain. Due to the rarity of these lesions, they are frequently misdiagnosed and treated inappropriately. We managed a 6-year-old girl with preseptal AVM by endovascular embolization followed by complete surgical excision after 2 days. She was previously diagnosed as capillary hemangioma and was being treated with intralesional steroid injections and oral propranolol. Neuroimaging revealed an AVM fed by the branches of both external and internal carotid arteries and drained by the superior ophthalmic vein. Endovascular embolization with glue followed by complete surgical excision of the lesion was done. The resultant cosmetic and functional outcome was gratifying. Diagnosis and management of periorbital AVM remain a challenge requiring a multidisciplinary approach involving interventional radiologist and trained oculoplastic surgeons. Combined endovascular embolization followed by surgical excision proved safe and effective.
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- 2018
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25. Malignant perivascular epithelioid cell tumor of the orbit: Report of a case and review of literature.
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Alam MS, Mukherjee B, Krishnakumar S, and Biswas J
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- Child, Preschool, Combined Modality Therapy, Diagnosis, Differential, Eye Neoplasms therapy, Humans, Magnetic Resonance Imaging, Male, Perivascular Epithelioid Cell Neoplasms therapy, Photomicrography, Eye Neoplasms diagnosis, Orbit diagnostic imaging, Perivascular Epithelioid Cell Neoplasms diagnosis
- Abstract
Perivascular epithelioid cell tumor (PEComa) is a rare neoplasm considered to arise from myomelanocytic cell lineage. The uterus is reportedly the most common site to be involved. Orbital PEComa is extremely rare with only two cases reported till date. A 5-year-old male presented with a right medial orbital mass for the last 6 months. The patient was diagnosed with alveolar soft part sarcoma elsewhere. Magnetic resonance imaging features were suggestive of lymphangioma with bleeding. The excision biopsy revealed multiple tumor cells comprising epithelioid cells with clear cytoplasm, along with nuclear atypia and mitosis. Immunohistochemistry was positive for HMB-45, smooth muscle actin, vimentin, and CD-34. It was negative for cytokeratin, S-100, and synaptophysin, which clinched the diagnosis of malignant orbital PEComa. Neoadjuvant chemotherapy was administered. There was no recurrence at 24 months of follow-up. At present, there is no consensus on management protocol for malignant PEComa. Complete surgical excision with chemotherapy appears to offer the best prognosis.
- Published
- 2017
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26. Lacrimal gland myxoma.
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Parikh D and Mukherjee B
- Subjects
- Aged, Biopsy, Diagnosis, Differential, Eye Neoplasms surgery, Humans, Lacrimal Apparatus surgery, Male, Myxoma surgery, Tomography, X-Ray Computed, Eye Neoplasms diagnosis, Lacrimal Apparatus diagnostic imaging, Myxoma diagnosis, Ophthalmologic Surgical Procedures methods
- Abstract
Myxomas are rare neoplasms of mesenchymal origin. Cases of conjunctival, corneal, and orbital myxomas have been reported in the literature; however, to the best of our knowledge, there is no report of a lacrimal gland myxoma. We report a case of an orbital myxoma involving the lacrimal gland and its management.
- Published
- 2017
- Full Text
- View/download PDF
27. Timing of surgery in traumatic globe dislocation.
- Author
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Alam MS, Noronha OV, and Mukherjee B
- Subjects
- Eye Injuries diagnosis, Female, Humans, Magnetic Resonance Imaging, Maxillary Sinus, Middle Aged, Orbital Fractures diagnosis, Tomography, X-Ray Computed, Visual Acuity, Wounds, Nonpenetrating diagnosis, Eye Injuries surgery, Ophthalmologic Surgical Procedures methods, Orbital Fractures surgery, Time-to-Treatment, Wounds, Nonpenetrating surgery
- Abstract
Traumatic globe dislocation into the maxillary sinus is a rare event and usually associated with a poor visual outcome if not managed appropriately. We report a 45-year-old female patient who presented to the emergency after blunt injury to her face with a door. Initial evaluation revealed nil perception of light and an apparently anophthalmic socket. Neuroimaging revealed large floor and medial wall fracture with dislocation of the globe into the maxillary sinus. The patient underwent exploration with repositioning of the globe and fracture repair. She was also administered 1 g intravenous methylprednisolone along with tapering course of oral steroids for 3 days. Patient's final visual acuity at 18 months of follow-up improved to counting fingers at 1 m. A thorough review of the literature suggests immediate surgery might improve the final visual outcome in such cases.
- Published
- 2017
- Full Text
- View/download PDF
28. A rare case of pachydermoperiostosis associated with blepharoptosis and floppy eyelids.
- Author
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Mukherjee B and Alam MS
- Subjects
- Adult, Biopsy, Blepharoptosis surgery, Eyelids surgery, Humans, Male, Meibomian Glands diagnostic imaging, Rare Diseases, Blepharoptosis etiology, Eyelids pathology, Osteoarthropathy, Primary Hypertrophic complications
- Abstract
Pachydermoperiostosis (PDP) is a multisystem disorder of mesenchymal origin. It is a form of hypertrophic osteoarthropathy. The typical clinical features include pachydermia, cutis verticus gyrata, digital clubbing, and periostosis. Patients present with mechanical ptosis resulting from markedly thickened eye lids. Floppy eye lids have rarely been reported in association with PDP. We describe a rare case of PDP associated with ptosis and floppy eye lids in an adult male. Meibomian gland dysfunction was documented by meibography. The patient underwent bilateral upper lid wedge resection, lateral tarsal strip, tarsectomy and external levator advancement with good cosmetic outcome following surgery.
- Published
- 2016
- Full Text
- View/download PDF
29. Nasolacrimal duct obstruction: Does it really increase the risk of amblyopia in children?
- Author
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Ramkumar VA, Agarkar S, and Mukherjee B
- Subjects
- Amblyopia epidemiology, Child, Preschool, Female, Follow-Up Studies, Humans, India epidemiology, Infant, Lacrimal Duct Obstruction congenital, Lacrimal Duct Obstruction diagnosis, Male, Prevalence, Retrospective Studies, Risk Factors, Amblyopia etiology, Lacrimal Duct Obstruction complications, Nasolacrimal Duct abnormalities, Risk Assessment methods, Visual Acuity
- Abstract
Purpose: To report the prevalence of amblyopia risk factors in children with congenital nasolacrimal duct obstruction., Methods: A retrospective review of records of children with the diagnosis of congenital nasolacrimal duct obstruction (NLDO), who underwent probing from January 2009 to October 2011, was done. All of them underwent a complete ophthalmic evaluation including cycloplegic refraction and strabismus evaluation before probing., Results: A total of 142 children were included in this study. The mean age at presentation was 22.38 months (sample standard deviation (SSD) - 15.88). Amblyopia risk factors were defined according to two sets of guidelines: The American Association for Pediatric Ophthalmology and Strabismus (AAPOS) referral criteria guidelines and the new AAPOS Vision Screening Committee guidelines. Twenty-eight (20%) children were found to have some form of amblyopia risk factor based on the referral criteria prescribed by AAPOS. However, on applying modified guidelines described by Donahue et al., to analyze the same cohort, 21 children were found to have amblyogenic risk factors. Of these 28 children, 13 had significant astigmatism (>1.50 D), 8 children had hypermetropia (>3.50 D), and six children had anisometropia (>1.50 D). One child had significant cataract (media opacity >1 mm). None of the children in this series had either myopia or strabismus., Conclusion: Prevalence of amblyopia risk factor was found to be 20% in our study based on the older guidelines; however, it reduces to 14.78% by applying the modified guidelines. Despite this reduction, importance of a comprehensive ophthalmic examination including cycloplegic refraction in all children presenting with NLDO cannot be overstated. A close follow-up of these children is also essential to prevent the development of amblyopia.
- Published
- 2016
- Full Text
- View/download PDF
30. Prostaglandin-associated periorbitopathy.
- Author
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Shrirao N, Khurana M, and Mukherjee B
- Subjects
- Antihypertensive Agents administration & dosage, Antihypertensive Agents adverse effects, Bimatoprost administration & dosage, Humans, Male, Middle Aged, Ophthalmic Solutions, Orbital Diseases, Bimatoprost adverse effects, Glaucoma, Open-Angle drug therapy, Prostaglandins adverse effects
- Published
- 2016
- Full Text
- View/download PDF
31. Fungal infections of the orbit.
- Author
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Mukherjee B, Raichura ND, and Alam MS
- Subjects
- Eye Infections, Fungal drug therapy, Humans, Orbital Diseases drug therapy, Antifungal Agents therapeutic use, Eye Infections, Fungal microbiology, Orbit microbiology, Orbital Diseases microbiology
- Abstract
Fungal infections of the orbit can lead to grave complications. Although the primary site of inoculation of the infective organism is frequently the sinuses, the patients can initially present to the ophthalmologist with ocular signs and symptoms. Due to its varied and nonspecific clinical features, especially in the early stages, patients are frequently misdiagnosed and even treated with steroids which worsen the situation leading to dire consequences. Ophthalmologists should be familiar with the clinical spectrum of disease and the variable presentation of this infection, as early diagnosis and rapid institution of appropriate therapy are crucial elements in the management of this invasive sino-orbital infection. In this review, relevant clinical, microbiological, and imaging findings are discussed along with the current consensus on local and systemic management. We review the recent literature and provide a comprehensive analysis. In the immunocompromised, as well as in healthy patients, a high index of suspicion must be maintained as delay in diagnosis of fungal pathology may lead to disfiguring morbidity or even mortality. Obtaining adequate diagnostic material for pathological and microbiological examination is critical. Newer methods of therapy, particularly oral voriconazole and topical amphotericin B, may be beneficial in selected patients.
- Published
- 2016
- Full Text
- View/download PDF
32. Authors' response.
- Author
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Mukherjee B and Alam MS
- Published
- 2015
33. Lipoid proteinosis: A rare entity.
- Author
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Mukherjee B and Devi PN
- Subjects
- Adult, Biopsy, Diagnosis, Differential, Humans, Male, Tomography, X-Ray Computed, Eyelid Diseases diagnosis, Eyelids pathology, Lipoid Proteinosis of Urbach and Wiethe diagnosis, Rare Diseases
- Abstract
Urbach-Wiethe syndrome or lipoid proteinosis is a rare autosomal recessive disorder characterized histologically by infiltration of Periodic acid Schiff-positive hyaline material in the skin, upper aerodigestive tract, eyelids, and internal organs. Classical clinical features include scarring of the skin, beaded eyelid papules (moniliform blepharosis) and laryngeal infiltration leading to hoarseness of voice. Lipoid proteinosis can lead to life-threatening conditions such as acute respiratory distress and seizures. Awareness among ophthalmologists about this rare entity is crucial for appropriate management of these patients.
- Published
- 2015
- Full Text
- View/download PDF
34. Acute visual loss with ophthalmoplegia after spinal surgery: report of a case and review of the literature.
- Author
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Mukherjee B and Alam MS
- Subjects
- Acute Disease, Adolescent, Blindness, Cortical diagnosis, Blindness, Cortical physiopathology, Humans, Male, Ophthalmoplegia diagnosis, Ophthalmoplegia physiopathology, Osteoblastoma surgery, Spinal Neoplasms surgery, Tomography, X-Ray Computed, Blindness, Cortical etiology, Cervical Vertebrae surgery, Ophthalmoplegia etiology, Orthopedic Procedures adverse effects, Postoperative Complications, Visual Acuity physiology
- Abstract
We report a case of a 15-year-old boy who presented with profound visual loss and complete ophthalmoplegia after an uneventful spinal surgery for removal of cervical osteoblastoma. Postoperative visual loss following nonocular surgery is, fortunately rare, yet a devastating complication. The most common cause is ischemic optic neuropathy, but it can also be due to central retinal occlusion or cortical blindness. Visual loss in conjunction with ophthalmoplegia is rarely seen, and there are very few reports in the literature. We also review the related literature and highlight the mechanism and preventive measures.
- Published
- 2014
- Full Text
- View/download PDF
35. Infestation of the lacrimal sac by Rhinosporidium seeberi: a clinicopathological case report.
- Author
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Mukherjee B, Mohan A, Sumathi V, and Biswas J
- Subjects
- Adult, Animals, Diagnosis, Differential, Endoscopy, Eye Infections, Parasitic parasitology, Eye Infections, Parasitic surgery, Humans, Lacrimal Apparatus Diseases parasitology, Lacrimal Apparatus Diseases surgery, Male, Nasolacrimal Duct parasitology, Ophthalmologic Surgical Procedures methods, Rhinosporidiosis parasitology, Rhinosporidiosis surgery, Eye Infections, Parasitic pathology, Lacrimal Apparatus Diseases pathology, Nasolacrimal Duct pathology, Rhinosporidiosis pathology, Rhinosporidium isolation & purification
- Abstract
Rhinosporidium seeberi , till recently known as a fungus, has been reclassified as a protistan parasite. It infects humans and many animal species. The authors describe a rare case of oculosporidiosis with involvement of the lacrimal sac exhibiting features of idiopathic orbital inflammatory disease in a young male patient. Clinical features, pathophysiology, and management of lacrimal sac rhinosporidiosis have been discussed.
- Published
- 2013
- Full Text
- View/download PDF
36. Reverse masquerade syndrome: fungal adnexal infection mimicking carcinoma in a HIV-positive patient.
- Author
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Mukherjee B, Chatterjee R, and Biswas J
- Subjects
- Biopsy, Candida albicans isolation & purification, Candidiasis microbiology, Diagnosis, Differential, Eye Infections, Fungal microbiology, Eyelid Diseases microbiology, Eyelids pathology, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Syndrome, Candidiasis diagnosis, Carcinoma, Squamous Cell diagnosis, Eye Infections, Fungal diagnosis, Eyelid Diseases diagnosis, Eyelid Neoplasms diagnosis, Eyelids microbiology, HIV Seropositivity complications
- Abstract
A known HIV-positive male patient presented with a rapidly progressive ulcerative lesion involving the conjunctiva, lids, and anterior orbit along with a decrease in vision in the right eye. He was on anti retro-viral and anti-tubercular therapy. In view of the clinical features, our provisional clinical diagnosis was a malignant lesion of the eyelid with orbital involvement, possibly squamous cell carcinoma. However, incisional biopsy revealed absence of malignant cells. On Gomori Methenamine Silver staining, plenty of fungal filaments were seen, which was confirmed by culture as Candida albicans. Hence, it turned out to be a case of fungal adnexal infection mimicking carcinoma in a HIV-positive patient. The patient responded well to systemic anti-fungals.
- Published
- 2013
- Full Text
- View/download PDF
37. Visual recovery after managing traumatic cataracts.
- Author
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Adulkar NG and Mukherjee B
- Subjects
- Female, Humans, Male, Cataract etiology, Cataract Extraction, Eye Injuries complications, Recovery of Function, Vision, Ocular
- Published
- 2013
- Full Text
- View/download PDF
38. Principles and practice of external digital photography in ophthalmology.
- Author
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Mukherjee B and Nair AG
- Subjects
- Adult, Child, Female, Humans, Male, Diagnostic Techniques, Ophthalmological standards, Eye Diseases diagnosis, Image Processing, Computer-Assisted standards, Photography standards, Practice Guidelines as Topic
- Abstract
It is mandatory to incorporate clinical photography in an ophthalmic practice. Patient photographs are routinely used in teaching, presentations, documenting surgical outcomes and marketing. Standardized clinical photographs are part of an armamentarium for any ophthalmologist interested in enhancing his or her practice. Unfortunately, many clinicians still avoid taking patient photographs for want of basic knowledge or inclination. The ubiquitous presence of the digital camera and digital technology has made it extremely easy and affordable to take high-quality images. It is not compulsory to employ a professional photographer or invest in expensive equipment any longer for this purpose. Any ophthalmologist should be able to take clinical photographs in his/her office settings with minimal technical skill. The purpose of this article is to provide an ophthalmic surgeon with guidelines to achieve standardized photographic views for specific procedures, to achieve consistency, to help in pre-operative planning and to produce accurate pre-operative and post-operative comparisons, which will aid in self-improvement, patient education, medicolegal documentation and publications. This review also discusses editing, storage, patient consent, medicolegal issues and importance of maintenance of patient confidentiality.
- Published
- 2012
- Full Text
- View/download PDF
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