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Background and Objectives: The second peak of coronavirus disease-2019 (COVID-19) experienced by India in April-May 2021 overwhelmed the health care system. A severe shortage of oxygen was experienced, and it was realized that some method of estimating the oxygen consumption should be available in order to streamline the distribution network of oxygen. Methods: In this paper, the authors propose a method of estimating the daily oxygen consumption for a hospital based on different formulae used to calculate oxygen consumption by various oxygen therapy devices. The proposed method was tested for its accuracy by measuring the actual oxygen consumption during the same period on the basis of pressure gauge readings difference observed on the liquid oxygen tank. The estimated and actual oxygen consumption was calculated each day for a period of 10 days. Results: The mean estimated oxygen consumption was 1.26±0.11 metric Tonne (MT), and the actual consumption was 1.34±0.08 MT. The estimated and actual consumption had a positive and significant correlation between them (correlation coefficient of 0.699). Reliability analysis performed using the Cronbach’s alpha revealed a factor of 0.94 as a coefficient between both variables indicating that the actual and calculated oxygen consumptions are nearly equal. The Bland and Altman analysis revealed a good agreement. Interpretation and Conclusions: It is concluded that the total oxygen requirement can be reliably estimated based on the proposed formulae, which can be useful to estimate the oxygen consumption of different hospitals, and plan the distribution of oxygen in a city or a district as a part of preparedness to deal with future surges of COVID-19 infections, if any. [ABSTRACT FROM AUTHOR]