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Start Over Author "Gupta, Amit" Journal indian journal of transplantation
38 results on '"Gupta, Amit"'

3. A comparative analysis of live-related ABO-incompatible and ABO-compatible renal transplantation: Effect of Vitamin D deficiency on antibody-mediated rejection - A retrospective observational study.

Author

Yachha, Monika, Sharma, Raj, Mehrotra, Sonia, Prasad, Narayan, Gupta, Amit, Bhadauria, Dharmendra, and Kaul, Anupama

Abstract

Background: ABO incompatible (ABOi) transplantation is a relatively newer option for renal transplant. Despite the encouraging results and the presence of organ shortage, it is still not routine in many developing countries. This can be attributed to the lack of experience, lack of technical infrastructure, and financial limitations. Objectives: Our study aimed to compare the outcomes of living-donor ABOi renal transplantation with matched recipients of ABO-compatible (ABOc) transplantation. We also assessed the impact of Vitamin D deficiency on posttransplant outcomes in terms of graft function and rejections in these groups. Methods: We retrospectively analyzed the results of 33 ABOi living-donor kidney transplants performed between January 2013 and June 2016 at our center. We compared patient and graft survival, acute rejection episodes, Vitamin D status, and graft function of the ABOi group with an equal number of matched live-related ABOc KTs done during the same time period. Results: The patient survival in both the groups was 97%; however, death-censored graft survival was 94% in the ABOi recipients versus 100% in ABOc group over a mean follow-up of 14–15 months, respectively. Graft function was overall better in the ABOc recipients, with statistical significance seen at 6 and 12 months posttransplant. We also observed a significantly higher incidence of acute antibody-mediated rejections (ABMRs) in the ABOi cohort, with 11 episodes of ABMR versus just 2 in the ABOc recipients (P = 0.005). Vitamin D deficiency was associated with higher levels of anti-ABO antibody and increased development of ABMR due to anti-ABO antibodies (P = 0.01). Conclusions: ABO incompatible transplantation is an option with excellent patient and graft survival; results almost comparable to the ABO compatible grafts. However, in our study, ABOi transplants were associated with higher risk of acute ABMR. These episodes were amenable to treatment, and thus, the overall graft survival had similar outcomes. Vitamin D deficiency was associated with increased ABMR in ABOi cohort of renal transplantation. [ABSTRACT FROM AUTHOR]

Published
2021
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4. Coronavirus disease in a renal allograft recipient: A case report.

Author

Gulati, Yuvraj, Prasad, Narayan, Behera, Manas, Patel, Manas, Bhadauria, Dharmendra, Kaul, Anupama, Yachha, Monika, Kushwaha, Ravi, and Gupta, Amit

Abstract

Coronavirus disease-19 (COVID-19) affected everyone on the globe, including renal transplant recipients who are at increased risk of infection. The clinical manifestations, immunosuppressive modifications, and treatment protocol are not well defined. We are reporting a case of renal transplant recipient and reviewed all case reports and series (a total of 100 patients) published to date to comprehend the clinical manifestations, immunosuppression modifications, treatment given, and outcomes of the patients. A 57-year-old male kidney transplant recipient had a fever, headache, weakness, and positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. He became asymptomatic with the treatment of hydroxychloroquine, azithromycin, and oseltamivir. However, he remained persistently positive by reverse transcriptase-polymerase chain reaction for SARS-CoV-2 for 4 weeks and became negative only after Ivermectin therapy, a safer medicine than antivirals/antiretrovirals used for COVID therapy in renal transplant recipients. Of the 100 patients review of case series, fever was noted in 85%, cough 71%, diarrhea 10%, and radiographic abnormalities in 75% of cases. Only in 3% of cases, steroid was stopped, and in the rest of the cases, 63% either continued in the same doses or changed to methylprednisolone in 34%. Calcineurin inhibitors were temporarily stopped in 42% of cases, reduced in 9% of cases, and continued in the same doses in 49% of cases. The anti-metabolites were discontinued in 83%, reduced in 9% of cases, and not changed in 8% of cases. SARI was observed in 18% and acute kidney injury (AKI) in 26% of cases. Of all the AKI, 11% required renal replacement therapy. Mortality was observed in 21% of cases. COVID in renal transplant recipients may show an unusually longer positivity. Ivermectin may be used in the absence of any conclusive SARS-CoV-2 antivirals. Mortality is high in renal transplant recipients. [ABSTRACT FROM AUTHOR]

Published
2020
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37. Immunosuppression induced acute pancreatitis in renal transplant recipient – Imaging and interventional management.

Author

Lal, Hira, Thakral, Anuj, Suryakant, Naik, Suprava, Munjal, Sachin, Rai, Praveer, Prasad, Narayan, Gupta, Amit, and Sharma, R.K.

Abstract

Abstract: Acute pancreatitis is a rare but often lethal complication in post-transplant patients. We describe a case of acute pancreatitis in a male patient 11 years after renal transplantation with azathioprine for immunosuppression as possible causative agent. Laboratory and imaging diagnosis of acute pancreatitis followed by successful endoscopic interventional management using transgastric catheter drainage is presented. [Copyright &y& Elsevier]

Published
2013
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38. Interventional management of iliopsoas abscess in a post renal transplant patient.

Author

Hiralal, Madhvi, Thakral, Anuj, Prasad, Narayan, Kaul, Anupama, Bhadauria, Dharmendera, Gupta, Amit, and Sharma, R.K.

Abstract

Abstract: Various types of collections can occur around the transplanted kidney. We present one such rare complication of psoas abscess underneath the transplanted kidney. Patient was on immunosuppression therapy post transplant and already had pulmonary tuberculosis treated with anti-tubercular treatment. Psoas abscess was diagnosed on subsequent follow up and managed successfully with ultrasound guided placement of percutaneous drainage catheter along with antibiotic therapy based on the culture report. Percutaneous drainage in combination with antibiotics is a viable alternative to more invasive surgical drainage for management of psoas abscess in post transplant patients. [Copyright &y& Elsevier]

Published
2013
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