1. Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection
- Author
-
Mas Marques, Andreas, Mueller, Tobias, Welke, Justus, Taube, Stefan, Sarrazin, Christoph, Wiese, Manfred, Halangk, Juliane, Witt, Heiko, Ahlenstiel, Golo, Spengler, Ulrich, Goebel, Uwe, Schott, Eckart, Weich, Viola, Schlosser, Beate, Wasmuth, Hermann E., Lammert, Frank, Berg, Thomas, and Schreier, Eckart
- Subjects
- *
LOW density lipoproteins , *BIOLOGICAL variation , *HEPATITIS C virus , *HEPATITIS C treatment , *NUCLEOTIDES , *ANTIVIRAL agents , *INTERFERONS , *RIBAVIRIN - Abstract
Abstract: Low-density lipoprotein receptor (LDLR) is involved in the entry of hepatitis C virus (HCV) in host cells. We investigated whether three single-nucleotide alterations within LDLR might be associated with the course of hepatitis C infection and response to antiviral therapy. We enrolled 651 individuals with chronic HCV infection who had received interferon-based combination therapy, 174 individuals with self-limited HCV infection, and 516 healthy controls. LDLR c.1171G>A, c.1413G>A, and c.*52G>A genotyping was performed by real-time PCR-based assays. HCV genotype 1-infected individuals who were homozygous for 3′UTR c.*52G were at increased risk for virologic non-response to antiviral therapy compared to virologic responders (66.3% vs. 51.0%, p = 0.001). Furthermore, compared to healthy controls, self-limited HCV genotype 1 infection was significantly associated with c.1171A (15.1% vs. 6.6%, p = 0.006) and negatively associated with c.1413G>A heterozygosity (33.0% vs. 46.1%, p = 0.023). The data indicate that LDLR alterations are correlated with response to interferon-based combination therapy and with self-limitation of HCV 1 infection. [Copyright &y& Elsevier]
- Published
- 2009
- Full Text
- View/download PDF