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2 results on '"Joon Yong Bae"'

1. Nosocomial Outbreak of COVID-19 in a Hematologic Ward

Author

Jiwon Jung, Ji Yeun Kim, Jungmin Lee, Seongman Bae, Man Seong Park, Seongmin Jo, Joon Yong Bae, Young Ju Lim, Sun Hee Kwak, Hye Hee Cha, Minki Sung, Eun Ok Kim, Changmin Kang, Sung-Han Kim, and Min Jee Hong

Subjects
2019-20 coronavirus outbreak, Hematologic malignancy, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Multi-patient room, Airborne transmission, 03 medical and health sciences, 0302 clinical medicine, medicine, Pharmacology (medical), 030212 general & internal medicine, Close contact, 0303 health sciences, Nosocomial outbreak, 030306 microbiology, business.industry, SARS-CoV-2, COVID-19, medicine.disease, Infectious Diseases, Original Article, Medical emergency, business, Contact tracing
Abstract

BACKGROUND: Coronavirus disease 2019 (COVID-19) outbreaks occur in hospitals in many parts of the world. In hospital settings, the possibility of airborne transmission needs to be investigated thoroughly. MATERIALS AND METHODS: There was a nosocomial outbreak of COVID-19 in a hematologic ward in a tertiary hospital, Seoul, Korea. We found 11 patients and guardians with COVID-19 through vigorous contact tracing and closed-circuit television monitoring. We found one patient who probably had acquired COVID-19 through airborne-transmission. We performed airflow investigation with simulation software, whole-genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RESULTS: Of the nine individuals with COVID-19 who had been in the hematologic ward, six stayed in one multi-patient room (Room 36), and other three stayed in different rooms (Room 1, 34, 35). Guardian in room 35 was close contact to cases in room 36, and patient in room 34 used the shared bathroom for teeth brushing 40 minutes after index used. Airflow simulation revealed that air was spread from the bathroom to the adjacent room 1 while patient in room 1 did not used the shared bathroom. Airflow was associated with poor ventilation in shared bathroom due to dysfunctioning air-exhaust, grill on the door of shared bathroom and the unintended negative pressure of adjacent room. CONCLUSION: Transmission of SARS-CoV-2 in the hematologic ward occurred rapidly in the multi-patient room and shared bathroom settings. In addition, there was a case of possible airborne transmission due to unexpected airflow.

Published
2021

2. Neutralizing antibody responses to SARS-CoV-2 and Its Clinical implications.

Author

Yoonjung Kim, Sohyun Bae, Soyoon Hwang, Kitae Kwon, Hyun-Ha Chang, Shin-Woo Kim, Joon-Yong Bae, and Manseong Park

Subjects
SARS-CoV-2, ANTIBODY formation, COVID-19 pandemic, VACCINE development, COVID-19
Abstract

배경 The COVID-19 pandemic caused by SARS-CoV-2 coronavirus threatens global public health. However, until now, no specific treatment or vaccine has been identified for COVID-19 infections, and it is not yet known how long the antibodies, including defensive neutralizing antibody (Nab), will last in patients with COVID-19. In order to treat for the COVID-19 infection and to have data for the development of SARS-CoV-2 vaccines, research of antibody characteristics according to clinical manifestation is urgently needed. 방법 From Jun 3rd to Jun 23th, blood samples were collected from 143 PCR-confirmed COVID-19 recovered patients who agreed to participate in the antibody tracking study at the Kyungpook National University Hospital. Patients under 18 years or with mental illness were excluded. Nab analysis (plaque reduction neutralization test; PRNT) was conducted by Korea University. A survey of clinical features was conducted through an individualized questionnaire, and an epidemiological and clinical data from Daegu City. We evaluated the relations of the clinical characteristics and Nab titer (≥1:40 or <1:40). 결과 Of the total 143 patients, 68 (47.6 %) were male and 75 (52.4 %) were female. Age distribution was as follows: 34 (23.8%) patients age range 20-29; 24 (16.8%) patients age range 30-39; 25 (17.5%) patients age range 40-49; 27 (18.9%) patients age range 50-59; and 33 (23.1%) patients age range 60-69. The average days taken from the symptom onset to the blood collection date was 109.0 [104.0; 115.0]. 32 patients (22.4%) showed < 1:40 Nab titer and 111 patients (77.6%) showed ≥1:40. As time went by, the rate of Nab titer ≥1:40 showed a tendency to slow decrease (figure 1). As the age was older, the rate of Nab titer ≥1:40 showed a statistically significance increasing tendency (p<0.001)(figure 2). The symptoms of dyspnea and presence of pneumonia were statistically significantly higher in groups of ≥1:40, but there were no other symptoms differences, including fever, sore throat, ageusia, anosmia and upper respiratory symptoms. No statistical differences were identified in gender, underlying diseases and ICU admission history between the two groups. 결론 After 3 months of COVID-19 infection, all recovered patients were found to have Nab, and 77.6% showed Nab levels ≥1:40. In order to prepare the convalescent serum antibody treatment and to establish vaccine policies in the near future, continuous tracking of changes in Nab is needed. [ABSTRACT FROM AUTHOR]

Published
2020

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