1. Th1 Cell Development Induced by Cysteine Proteinases A and B in Localized Cutaneous Leishmaniasis Due to Leishmania guyanensis
- Author
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Pascalis, Hervé, Pascalis, Pascal, Lavergne, Anne, Bourreau, Eliane, Prévot-Linguet, Ghislaine, Kariminia, Amina, Pradinaud, Roger, Rafati, Sima, Launois, Pascal, Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and Institut Pasteur d'Iran
- Subjects
Protozoan Vaccines ,[SDV]Life Sciences [q-bio] ,Molecular Sequence Data ,030231 tropical medicine ,Immunology ,Leishmania guyanensis ,Protozoan Proteins ,Leishmaniasis, Cutaneous ,Antigens, Protozoan ,Biology ,Microbiology ,Interferon-gamma ,03 medical and health sciences ,0302 clinical medicine ,Cutaneous leishmaniasis ,parasitic diseases ,medicine ,Animals ,Humans ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Leishmania major ,Interleukin 4 ,030304 developmental biology ,0303 health sciences ,Base Sequence ,Kinetoplastida ,Leishmaniasis ,Th1 Cells ,medicine.disease ,biology.organism_classification ,Virology ,3. Good health ,Cysteine Endopeptidases ,Interleukin 10 ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Infectious Diseases ,Interleukin-2 ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Parasitology ,Interleukin-4 ,Fungal and Parasitic Infections ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Cysteine - Abstract
The cysteine proteinases CPA and CPB from Leishmania major induced Th1 responses in patients with leishmaniasis due to Leishmania guyanensis . Furthermore, cysteine proteinases induced neither interleukin 4 (IL-4) nor IL-13 and low levels of IL-10 in controls and patients. The results suggest that CPs would be quite good candidates for a vaccine against different Leishmania species.
- Published
- 2003