1. Oral immunization with Acanthamoeba castellanii mannose-binding protein ameliorates amoebic keratitis.
- Author
-
Garate M, Alizadeh H, Neelam S, Niederkorn JY, and Panjwani N
- Subjects
- Administration, Oral, Animals, Cricetinae, Cricetulus, Disease Models, Animal, Immunoglobulin A, Secretory analysis, Mannose-Binding Lectin immunology, Recombinant Proteins immunology, Tears immunology, Acanthamoeba Keratitis prevention & control, Acanthamoeba castellanii, Immunization methods, Mannose-Binding Lectin administration & dosage, Recombinant Proteins administration & dosage
- Abstract
Acanthamoeba castellanii mannose-binding protein (MBP) mediates adhesion of the amoebae to corneal epithelial cells, a key first step in the pathogenesis of Acanthamoeba keratitis (AK), a devastating corneal infection. In the present study, we demonstrate that oral immunization with recombinant MBP ameliorates AK in a hamster animal model and that this protection is associated with the presence of elevated levels of anti-MBP immunoglobulin A in the tear fluid of the immunized animals.
- Published
- 2006
- Full Text
- View/download PDF