1. HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients.
- Author
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Rivera-Peña, Bianca, Ruíz-Fullana, Francisco J., Vélez-Reyes, Germán L., Rodriguez-Benitez, Rosa J., Marcos-Martínez, María J., Trinidad-Pinedo, Juan, and Báez, Adriana
- Subjects
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PAPILLOMAVIRUS disease diagnosis , *FISHER exact test , *EVALUATION of medical care , *ONCOGENES , *PAPILLOMAVIRUS diseases , *PAPILLOMAVIRUSES , *POLYMERASE chain reaction , *PROGNOSIS , *REGRESSION analysis , *SQUAMOUS cell carcinoma , *SURVIVAL analysis (Biometry) , *PROPORTIONAL hazards models , *KAPLAN-Meier estimator , *OROPHARYNGEAL cancer - Abstract
Background: HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. Methods: HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher's exact test and x². Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis. Results: OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (P = 0.002). HPV-16 positive tumors of the larynx (LSCC) and pharynx (PSCC) showed improved OS compared to HPV-16 negative tumors. Also, HPV-16 positive patients exposed to radiotherapy presented a better survival. Conclusions: HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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