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Edwardsiella tardainfection is infrequently encountered in humans. Exposure most often occurs through consumption of raw seafood or activities in bodies of fresh or brackish water, and systemic infections can have a high mortality rate. We present the case of a 32-year-old woman who presented with abdominal pain, nausea, vomiting, and diarrhea. She was septic and was started on broad-spectrum antibiotics after cultures were drawn. Imaging showed pyosalpinx/tubo-ovarian abscess that was refractory to systemic antibiotics and ultimately required surgical management. Two blood cultures and an intraoperative abscess culture grew pan-susceptible E. tarda. Postoperatively, the patient's clinical status quickly improved, and she was doing well at her follow-up visit. To the best of our knowledge, cases of E. tardabacteremia in the setting of tubo-ovarian abscess have not previously been reported, and this case is particularly unusual in that the patient is young and without predisposing chronic medical conditions.