1. Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study)
- Author
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Lourdes Albert-Botella, María Dolores Rodríguez Mulero, Leonor Nogales Martín, María José Fora Romero, Lucía Fernández Presa, Luis García de Guadiana-Romualdo, María Dolores Calvo, Marta Hernández Olivo, Ana Belen López Tarazaga, Isabel Llompart-Alabern, Cristina Bolado Jiménez, Edwin R Puerto-Lara, Leyre Pinilla Arribas, Celia Juez Santamaría, María Galindo Martínez, Aleksandra Mandic Havelka, Andrea Ballester Férriz, Valerio Campos-Rodríguez, Enrique Rodríguez-Borja, María Dolores Albaladejo-Otón, Carlos Rodríguez Rojas, Virginia Espinilla Fernández, Alexandra M Guiu-Martí, María Salomé Ros Braquehais, Wysalli Trapiello Fernández, Adela Pozo Giraldez, David Andaluz-Ojeda, Daniel Morell-Garcia, Juan Ortega-Pérez, and Antonieta Ballesteros-Vizoso
- Subjects
Adult ,Male ,medicine.medical_specialty ,Multivariate analysis ,Adolescent ,Neutrophils ,medicine.medical_treatment ,Immunology ,Neutrophil Activation ,law.invention ,Young Adult ,fluids and secretions ,Predictive Value of Tests ,law ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Original Research Article ,Invasive mechanical ventilation ,Prospective cohort study ,Aged ,Aged, 80 and over ,Inflammation ,Pharmacology ,Mechanical ventilation ,Calprotectin ,ICU admission ,business.industry ,COVID-19 ,Emergency department ,Middle Aged ,Respiration, Artificial ,Intensive care unit ,Intensive Care Units ,Treatment Outcome ,ROC Curve ,Respiratory failure ,Area Under Curve ,Immune System ,Multivariate Analysis ,Population study ,Female ,Respiratory Insufficiency ,business ,Leukocyte L1 Antigen Complex - Abstract
OBJECTIVE: Severe COVID-19 is characterized by a dysregulated immune response in which neutrophils play a critical role. Calprotectin reflects neutrophil activation and is involved in the self-amplifying thrombo-inflammatory storm in severe COVID-19. We aimed to evaluate the role of calprotectin in early prediction of severity in COVID-19 patients. METHODS: This was a multicenter prospective observational study enrolling consecutive adult COVID-19 patients. On arrival to emergency department, blood samples were collected for laboratory tests, including serum calprotectin. The primary outcome was severe respiratory failure requiring invasive mechanical ventilation and the secondary outcome was need for Intensive Care Unit (ICU) admission. RESULTS: Study population included 395 patients, 57 (14.4%) required invasive mechanical ventilation and 100 (25.3%) were admitted to ICU. Median serum calprotectin levels were significantly higher in intubated (3.73mg/L vs. 2.63mg/L; p
- Published
- 2021
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