1. Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohnʼs disease in Northern Europe
- Author
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G. Davies, Elaine R. Nimmo, Paraic McGrogan, Jack Satsangi, W M Bisset, Gamal Mahdi, Lawrence T. Weaver, Richard K Russell, Linda Smith, Hazel E. Drummond, I. D. R. Arnott, David C. Wilson, Niall Anderson, Peter M. Gillett, and J. van Limbergen
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Genotype ,Population ,Nod2 Signaling Adaptor Protein ,Autophagy-Related Proteins ,Disease ,Gastroenterology ,Inflammatory bowel disease ,Crohn Disease ,Gene Frequency ,Internal medicine ,Odds Ratio ,medicine ,Humans ,Immunology and Allergy ,Genetic Predisposition to Disease ,Age of Onset ,Child ,education ,Ileal Diseases ,ATG16L1 ,Alleles ,Crohn's disease ,education.field_of_study ,Polymorphism, Genetic ,business.industry ,DNA ,Middle Aged ,medicine.disease ,Phenotype ,Scotland ,Case-Control Studies ,Immunology ,Female ,Carrier Proteins ,business ,Body mass index - Abstract
The rs2241880A/G variant of the ATG16L1 gene has been associated with susceptibility to ileal Crohn's disease (CD) in adults. Our aim was to assess whether germline variation of ATG16L1 acts as an independent determinant of susceptibility to childhood-onset CD in the high-incidence Scottish population.In all, 2195 subjects (361 children (inflammatory bowel disease [IBD] diagnosis17 years), their parents (n = 634), 855 adult IBD patients, and 345 controls were genotyped. Case-control analysis was powered to detect effect sizes with an odds ratio (OR)1.39 in pediatric CD. Case-control analysis, transmission disequilibrium testing (TDT), analysis of variance (ANOVA) of growth parameter z-scores, Kruskal-Wallis test (age at diagnosis), and multifactorial genotype-phenotype analysis (Montreal classification) were performed. 7.8% of pediatric CD patients and 37.2% of adult CD patients had pure ileal disease.We confirmed the association of the rs2241880G-allele with adult-onset CD (60.7% versus controls 53.9%, P = 0.01, OR 1.32, 95% confidence interval [CI] 1.07-1.63) in contrast to childhood-onset CD (54.1% versus controls, P = 0.95, OR 1.01, 95% CI 0.80-1.26). TDT analysis was negative. Genotype-phenotype analysis demonstrated an association of pure ileal disease with the rs2241880G-allele (P = 0.02, OR 1.34, 95% CI 1.03-1.74). Using binary logistic regression analysis we confirmed the effect of rs2241880 genotype (GG) on ileal disease versus colonic disease (P = 0.03, OR 2.43, 95% CI 1.05-5.65). ATG16L1 genotype did not influence age at CD diagnosis. ANOVA of z-scores of height, weight, and body mass index (BMI) at CD diagnosis in children showed no association with genotype.The ATG16L1 variant is associated with susceptibility to adult CD in Scotland, but not early-onset disease. These contrasting effects are primarily driven by differences in disease location between early-onset and adult-onset disease.
- Published
- 2008
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