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This paper studies the problem of rescheduling trains with speed management in uncertain disruptions that lead to temporary speed restrictions (TSRs) in high-speed railway systems. The disruption uncertainties are that the coverage and speed limit value of TSRs change randomly over time, and the start and end times of TSRs are unknown in advance. First, a mixed-integer linear programming model is formulated to reduce the total train traveling times and improve the passenger comfortability. The solutions of the model provide simultaneously the optimal train rescheduling strategies and train speed control strategies. Second, a rolling horizon algorithm is applied in consideration of the disruption uncertainties. The rolling horizon algorithm updates and solves the model in every time horizon, according to the disruption information newly detected. Therefore, the train rescheduling orders and speed control orders can be adjusted according to the real-time situation to guarantee effectiveness. The rolling horizon approach is terminated automatically once the disruption ends. Finally, based on the practical data of the Beijing-Tianjin intercity high-speed railway line, numerical experiments are carried out to test the effectiveness and efficiency of the proposed approach. [ABSTRACT FROM AUTHOR]