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• This paper used wedge sample as a detection model. • This paper studied the changes of the diffuse disc properties. • This paper proposed the multi-dimension radial distance method. The measurement accuracy of turbid media is difficult to improve due to the co-existence of absorption and scattering effects. In this report, the diffuse disc of transmission surface was obtained by using the Monte Carlo simulation model based on wedge sample, and the radial distance of each diffuse disc was extracted to study the influence of different optical parameters on the diffuse disc properties. Subsequently, the partial least square regression (PLS) analysis model was established to analyze the relationship between multi-dimensional radial distance and the concentration of Intralipid-20%. Compared with multi-dimensional spectroscopy fusion (MDSF) and conventional two-dimensional light intensity method, multidimensional radial distance (MDRD) method increased the average correlation coefficient of prediction set by 3.5% and decreased the average mean square error by 28.6%. This study proposes the high-throughput and non-invasive method to analysis the turbid media using Monte Carlo simulation model based wedge sample. [ABSTRACT FROM AUTHOR]