1. Overview of the short- and long-term quantitative outcomes following end-to-side neurorrhaphy in a rat model
- Author
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O. Johnson Elizabeth, Zhang Zigie, and N. Soucacos Panayotis
- Subjects
medicine.medical_specialty ,End to side neurorrhaphy ,Rat model ,Neurosurgical Procedures ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,Animals ,Medicine ,Nerve repair ,Tibial nerve ,General Environmental Science ,030222 orthopedics ,Double labeling ,business.industry ,Anastomosis, Surgical ,Peroneal Nerve ,030208 emergency & critical care medicine ,Collateral sprouting ,Axons ,Nerve Regeneration ,Rats ,Surgery ,Time course ,General Earth and Planetary Sciences ,Female ,Tibial Nerve ,business - Abstract
The time course of events following end-to-side nerve coaptation remains unclear. Re-innervation and effects on the donor nerve were assessed following short- and long-term end-to-side neurorrhaphy were investigated in a rat model. One hundred and our Sprague-Dawley female rats were randomized to fresh and pre degenerated repair groups with or without perineurotomy. The right peroneal nerve was sutured to the tibial nerve in an end-to-side manner. Histological and electro-physiological assessment of re-innervation and of the donor nerve was performed at two-three months and at nine-twelve months, post-operatively. The results demonstrated that end-to-side neurorrhaphy could attract axonal sprouts and successfully re-innervate the target muscles. The influence on donor nerve was minimal in late stages, although it did have early negative effect. Double labeling provided evidence that one of the mechanisms of this procedure is probably by collateral sprouting.
- Published
- 2020