1. Synthesis, structure and cytotoxicity evaluation of complexes of N1-substituted-isatin-3-thiosemicarbazone with copper(I) halides.
- Author
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Khan, Ashiq, Jasinski, Jerry P., Smoleaski, Victoria A., Paul, Kamaldeep, Singh, Gurpinder, and Sharma, Rekha
- Subjects
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ISATIN , *THIOSEMICARBAZONES , *COPPER , *HALIDES , *CRYSTALLIZATION - Abstract
Synthesis of Isatin-N 1 -methyl-thiosemicarbazone (H 2 itsc-N 1 -Me, H 2 L 1 ) and isatin-N 1 -ethyl-thiosemicarbazone (H 2 itsc-N 1 -Et, H 2 L 2 ) has been carried out and the effect of substituents (at N 1 atom of isatin-3-thiosemicarbazones) on nuclearity of copper(I) halide complexes has been investigated. Reactions of copper(I) halides (X = I, Br, Cl) with H 2 L 1 and H 2 L 2 using Ph 3 P as co-ligand in 1:1:1 (M:L:PPh 3 ) molar ratio in acetonitrile yielded complexes of stoichiometry [CuX(H 2 L 1 )(Ph 3 P)] (X = I, C1 ; Br, C2 ; Cl, C3 ) and [CuX(H 2 L 2 )(Ph 3 P)] (X = I, C4 ; Br, C5 ; Cl, C6 ) respectively. All these complexes have been characterized using analytical and spectroscopic data (IR, 1 H NMR and ESI mass). The single crystal structure has been solved for H 2 L 1 and C2 . The complex C2 has distorted tetrahedral geometry around copper(I) and isatin-N 1 -methyl-thiosemicarbazone coordinated to metal center as neutral, bidentate, N 3 , S-chelating ligand. Elemental analysis suggested the presence of one acetonitrile molecule in complexes C3 and C6 and half CH 3 CN in complexes C2 and C4 as solvent of crystallization. MTT assay, supported by docking studies have revealed the cytotoxic nature of the compounds C1 – C6 . [ABSTRACT FROM AUTHOR]
- Published
- 2016
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