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This work reports the synthesis and structural characterization of a new adenine based organosilicon nucleobase using an efficient and biocompatible Click approach. Synthetic procedure included the preparation of a new N -acetylinic linked propyl silatrane 3 whose structure was confirmed through Single crystal X-ray crystallography. The designed silatrane L is found to be highly selective and sensitive for detection of Cu 2+ with a color change from colourless to yellowish orange. The stoichiometry ratio of L + Cu 2+ was obtained 1:1 by Job’s Plot. The binding of copper ions to the chemosensor was studied over wide pH range and the results demonstrated that the sensor worked well in the physiological range 6–9. Furthermore, the sensing of Cu 2+ was found to be reversible upon addition of EDTA. These results widen the scope of adenine based derivatives in the field of colorimetric probes. The newly synthesized silatrane 3 and the receptor L were successfully characterized by various spectroscopic techniques [IR, NMR ( 1 H, 13 C) and Mass] and elemental analysis. [ABSTRACT FROM AUTHOR]

A triazole tethered chemo sensor molecules with the capability of sensing cations have been synthesized by coupling two sensor based alkynyl indole schiff base unit to azide. The hybrid networks were able to donate electron via azomethine linkage, traizole ring and indole motif to bind copper and nickel effectively. Such indole based hybrids would have potential applications in biological systems. Indole traizoles (In-Tz) were synthesized under microwave irradiation with auto generated pressure (at 60 °C) and characterized by 1H NMR, 13C NMR, Mass and FTIR spectroscopy, thin-layer chromatography (TLC) and elemental analyses. The fabricated sensor exhibited higher sensitivity, large-dynamic concentration ranges and long term stability towards In-Tz conjugated copper and nickel complex for selective Cu 2+ and Ni 2+ sensor. The calibration plot is linear (r 2 : 0.9895, r 2 : 0.9808) over the large Cu 2+ ions and Ni 2+ concentration ranges (1.0 µM). This novel effort has initiated a well-organize way of efficient cationic sensor improvement with triazole for heavy metallic pollutants in environmental and health-care fields in large scales. [ABSTRACT FROM AUTHOR]