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The purpose of this review was to demonstrate the definition of the original symptom (OS) and how it works in medical procedures as to the Sasangmedicine based on the Jema Lee's Donguisusebowon(Longevity and Life Preservation in Eastern Medicine). OS is defined as the sum of all clinical information featured by an individual's intrinsic characteristics as Sasanginand health state prior to onset. It is the key factor in the clinical application of Sasangmedicine including the diagnosis of constitutional type and Sasangsymptomatology because the imbalance of metabolic functions of each Sasanginoriginates from that. The working principles of the OS and Sasangsymptomatology can be summarized as follows. First, clinical information regarding cold or heat intolerance determines the cold or heat pattern of Sasangsymptomatology. Another is the present worsening of the severity of Sasangsymptomatology by one level as compared with that in the past. Symptoms prior to the onset worsen to a higher level of severity after any disorder breaks out. Finally, the treatment strategy and progress of each Sasanginare determined following the characteristics of the OS. Theoretical and clinical studies should be conducted to show the specific criteria for the diagnosis of Sasangsymptomatology in the future.