1. Prevention of nosocomial maxillary sinusitis in the ICU: the effects of topically applied alpha-adrenergic agonists and corticosteroids
- Author
-
Vasiliki Theodorou, Georgios Vretzakis, Ioannis Pneumatikos, Vasilios Danielides, Demosthenes Bouros, Iraklis Tsagaris, and Dimitrios Konstantonis
- Subjects
Budesonide ,Adult ,Male ,medicine.medical_specialty ,Resuscitation ,Administration, Topical ,Critical Care and Intensive Care Medicine ,Placebo ,Gram-Positive Bacteria ,Xylometazoline ,Bacteria, Anaerobic ,Adrenal Cortex Hormones ,Intensive care ,Gram-Negative Bacteria ,medicine ,Humans ,Prospective Studies ,Sinusitis ,Cross Infection ,Greece ,business.industry ,Ventilator-associated pneumonia ,Middle Aged ,medicine.disease ,Maxillary Sinusitis ,Surgery ,Nasal decongestant ,Intensive Care Units ,Anesthesia ,Female ,business ,Adrenergic alpha-Agonists ,medicine.drug - Abstract
We investigated the efficacy of locally applied nasal decongestant agents and corticosteroids for preventing nosocomial maxillary sinusitis in mechanically ventilated patients with multiple trauma. A prospective, open-label randomized study in two intensive care units (ICUs). 79 consecutive multiple trauma patients admitted to the ICU who were expected to be mechanically ventilated for more than 3 days. Patients were randomly assigned to receive either a combination of a locally applied nasal decongestant agents: 2 drops twice/day of xylometazoline nasal solution 0.1% and 100 μg budesonide (NDCA group, n = 39) or placebo (control group, n = 40). For the diagnosis of radiological maxillary sinusitis patients underwent paranasal computed tomography within 48 h of admission and thereafter every 4–7 days. Infectious maxillary sinusitis was diagnosed by microbiological analysis of fluid aspirated after transnasal puncture of maxillary sinuses. Radiological maxillary sinusitis was detected in 54% of patients in the NDCA group (n = 21) but in 82% of controls (p
- Published
- 2006