Search

Your search keyword '"Kazuya, Shiogama"' showing total 3 results
Start Over Author "Kazuya, Shiogama" Journal internal medicine
3 results on '"Kazuya, Shiogama"'

1. Behçet's Disease with Bilateral Renal Infarction Due to Mucormycosis

Author

Kazuya Shiogama, Noriyoshi Ogawa, Naomi Morishita, Kumiko Shimoyama, Yuka Nagakura, Haruka Yonezawa, Masakazu Hatakeyama, Yusuke Okubo, Tomoyuki Niwa, Shogo Furukawa, Daisuki Suzuki, and Isao Kosugi

Subjects
Male, medicine.medical_specialty, Autopsy, Behcet's disease, Disease, urologic and male genital diseases, Gastroenterology, Refractory, Internal medicine, Internal Medicine, medicine, Humans, Mucormycosis, cardiovascular diseases, Glucocorticoids, Aged, business.industry, Behcet Syndrome, General Medicine, medicine.disease, stomatognathic diseases, Infarction, cardiovascular system, Tumor Necrosis Factor Inhibitors, Histopathology, Tumor necrosis factor alpha, business, Glucocorticoid, medicine.drug
Abstract

We herein report a case of Behçet's disease with renal infarction due to mucormycosis. A 76-year-old man with entero-Behçet's disease had been treated with glucocorticoid and tumor necrosis factor (TNF) inhibitors. His entero-Behçet's disease was refractory to these treatments, and ileocecal resection was performed. After the operation, renal infarction that was unresponsive to anticoagulation therapy developed. He ultimately died of renal failure due to renal infarction. At the autopsy, histopathology of abundant hyphae in the renal vessel wall revealed mucormycosis. Renal mucormycosis is an important cause of renal failure with renal infarction in immunocompromised patients.

Published
2022
Full Text
View/download PDF

3. Extranodal NK/T-cell Lymphoma, Nasal Type Accompanied by PR3-ANCA-associated Glomerulonephritis

Author

Yosuke Matsumoto, Michitsugu Kamezaki, Keiichi Tamagaki, Kazuya Shiogama, Yutaka Tsutsumi, Tetsuro Kusaba, Eiichi Konishi, Hiroshi Kado, Yuta Tamoto, Yoshiaki Chinen, and Ryo Ishida

Subjects
0301 basic medicine, Male, Pathology, medicine.medical_specialty, extranodal NK/T-cell lymphoma, Neutrophils, Myeloblastin, Nose Neoplasms, Case Report, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, urologic and male genital diseases, Nose neoplasm, Extranodal NK/T-cell lymphoma, nasal type, Antibodies, Antineutrophil Cytoplasmic, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Glomerulonephritis, immune system diseases, Internal Medicine, medicine, nasal type, Humans, cardiovascular diseases, skin and connective tissue diseases, biology, business.industry, apoptosis, Granulomatosis with Polyangiitis, neutrophil, General Medicine, Middle Aged, medicine.disease, Lymphoma, respiratory tract diseases, Lymphoma, Extranodal NK-T-Cell, 030104 developmental biology, proteinase 3 antineutrophil cytoplasmic antibodies, Apoptosis, 030220 oncology & carcinogenesis, biology.protein, Antibody, Granulomatosis with polyangiitis, business, Intracellular
Abstract

A 62-year-old man exhibiting nasal obstruction and glomerulonephritis with proteinase 3-antineutrophil cytoplasmic antibodies (PR3-ANCAs) was diagnosed with extranodal NK/T-cell lymphoma, nasal type (ENKL) with infiltration of neutrophils with apoptosis. Chemoradiotherapy reduced the tumor, improved the renal function, and decreased the PR3-ANCA levels. ANCA-positivity is observed in immunoinsufficient diseases, in which neutrophils lead to apoptosis and translocate intracellular granules, such as PR3, to the cell surface, triggering the production of ANCAs. In our case, the PR3-ANCA production was derived from the expression of PR3 on the cell surface of apoptotic neutrophils. This is the first report on ENKL describing the mechanism of ANCA development.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results