Search

Your search keyword '"Koichi Fukunaga"' showing total 7 results
Start Over Author "Koichi Fukunaga" Journal international archives of allergy and immunology
7 results on '"Koichi Fukunaga"'

1. Role of Prostaglandin D Receptor CRTH2 in Sustained Eosinophil Accumulation in the Airways of Mice with Chronic Asthma

Author

Yusuke Suzuki, Koichiro Asano, Masataka Nakamura, Koichi Fukunaga, Tokuhiro Kimura, Hiroyuki Hirai, Koichi Sayama, Kinya Nagata, Tetsuya Shiomi, Shizuko Kagawa, and Tsuyoshi Oguma

Subjects
medicine.medical_specialty, Immunology, Pathogenesis, chemistry.chemical_compound, Internal medicine, Eosinophilic, medicine, Immunology and Allergy, Asthma, Prostaglandin D2 receptor, medicine.diagnostic_test, biology, business.industry, General Medicine, respiratory system, Eosinophil, medicine.disease, Ovalbumin, Endocrinology, Bronchoalveolar lavage, medicine.anatomical_structure, chemistry, biology.protein, Prostaglandin D2, business
Abstract

The prostaglandin D2 (PGD2)/CRTH2 pathway is important for eosinophil trafficking in vitro; however, genetic deficiency of CRTH2 does not suppress in vivo eosinophilic airway inflammation in acute models of asthma, and the role of CRTH2 in the pathogenesis of asthma is still ambiguous. Therefore, in the present study we explored whether the PGD2/CRTH2 pathway could affect the phenotypes of chronic asthma. Either CRTH2-deficient (CRTH2–/–) or wild-type mice were sensitized and exposed to ovalbumin (OVA) for 3 days (acute model) or 6 weeks (chronic model). While the magnitude of the acute eosinophilic inflammation was equivalent between CRTH2–/– and wild-type mice, the number of inflammatory cells and eosinophils in bronchoalveolar lavage fluid after chronic OVA exposure was significantly reduced in CRTH2–/– mice (18.0 ± 2.6 × 104 cells and 2.0 ± 0.5 × 104 cells) compared to wild-type mice (27.9 ± 2.5 × 104 cells and 6.8 ± 1.1 × 104 cells, p < 0.001). On the contrary, no difference was observed between CRTH2–/– and wild-type mice in terms of airway hyperresponsiveness or remodeling (goblet cell hyperplasia) in the chronic model of asthma. In conclusion, CRTH2 that mediates PGD2 activity is essential for sustained eosinophilic inflammation in the airways, and its antagonists could exert an anti-inflammatory effect in chronic asthma.

Published
2011
Full Text
View/download PDF

2. Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma

Author

Shizuko, Kagawa, Koichi, Fukunaga, Tsuyoshi, Oguma, Yusuke, Suzuki, Tetsuya, Shiomi, Koichi, Sayama, Tokuhiro, Kimura, Hiroyuki, Hirai, Kinya, Nagata, Masataka, Nakamura, and Koichiro, Asano

Subjects
Male, Mice, Knockout, Mice, Inbred BALB C, Interleukin-13, Ovalbumin, Receptors, Prostaglandin, Vaccination, Mucins, Asthma, Eosinophils, Mice, Animals, Goblet Cells, Bronchial Hyperreactivity, Interleukin-5, Pulmonary Eosinophilia, Receptors, Immunologic, Bronchoalveolar Lavage Fluid, Lung, Methacholine Chloride
Abstract

The prostaglandin D(2) (PGD(2))/CRTH2 pathway is important for eosinophil trafficking in vitro; however, genetic deficiency of CRTH2 does not suppress in vivo eosinophilic airway inflammation in acute models of asthma, and the role of CRTH2 in the pathogenesis of asthma is still ambiguous. Therefore, in the present study we explored whether the PGD(2)/CRTH2 pathway could affect the phenotypes of chronic asthma. Either CRTH2-deficient (CRTH2-/-) or wild-type mice were sensitized and exposed to ovalbumin (OVA) for 3 days (acute model) or 6 weeks (chronic model). While the magnitude of the acute eosinophilic inflammation was equivalent between CRTH2-/- and wild-type mice, the number of inflammatory cells and eosinophils in bronchoalveolar lavage fluid after chronic OVA exposure was significantly reduced in CRTH2-/- mice (18.0 ± 2.6 × 10(4) cells and 2.0 ± 0.5 × 10(4) cells) compared to wild-type mice (27.9 ± 2.5 × 10(4) cells and 6.8 ± 1.1 × 10(4) cells, p0.001). On the contrary, no difference was observed between CRTH2-/- and wild-type mice in terms of airway hyperresponsiveness or remodeling (goblet cell hyperplasia) in the chronic model of asthma. In conclusion, CRTH2 that mediates PGD(2) activity is essential for sustained eosinophilic inflammation in the airways, and its antagonists could exert an anti-inflammatory effect in chronic asthma.

Published
2011

3. Strain-specific phenotypes of airway inflammation and bronchial hyperresponsiveness induced by epicutaneous allergen sensitization in BALB/c and C57BL/6 mice

Author

Hiromi Ogura, Koichiro Asano, Takahisa Takihara, Jun Miyata, Koichi Fukunaga, Katsuyoshi Tomomatsu, Shizuko Kagawa, Misa Wakaki, Motohiro Kodama, Taku Miyasho, Eiji Ikeda, Nao Ohmori, Tsuyoshi Oguma, Koichi Sayama, Nobufumi Kamiishi, Akitoshi Ishizaka, Soichiro Ueda, and Kyuto Tanaka

Subjects
Male, Allergy, Ovalbumin, Immunology, Inflammation, Cell Count, medicine.disease_cause, Bronchial Provocation Tests, BALB/c, Allergic sensitization, Interferon-gamma, Mice, Allergen, immune system diseases, Leukocytes, Immunology and Allergy, Medicine, Animals, Sensitization, Asthma, Mice, Inbred BALB C, biology, business.industry, Airway Resistance, Interleukins, General Medicine, Allergens, Immunoglobulin E, medicine.disease, biology.organism_classification, respiratory tract diseases, body regions, Eosinophils, Mice, Inbred C57BL, medicine.anatomical_structure, Phenotype, Bronchial hyperresponsiveness, Immunoglobulin G, Immunization, medicine.symptom, Bronchial Hyperreactivity, business, Bronchoalveolar Lavage Fluid
Abstract

Background: Allergen sensitization through a disrupted skin barrier appears to play a prominent role in the development of atopic diseases, including allergic asthma. The role of the genetic background in immunological and physiological phenotypes induced by epicutaneous sensitization is undetermined. Methods: BALB/c and C57BL/6 mice were sensitized either epicutaneously by patch application of ovalbumin (OVA) or systemically by intraperitoneal injection of OVA with alum before exposure to aerosolized OVA. The concentrations of OVA-specific immunoglobulin in serum and cytokines in bronchoalveolar lavage fluid (BALF) were measured by enzyme-linked immunosorbent assay. The severity of airway inflammation was evaluated by cell counts in BALF, and bronchial responsiveness to methacholine was measured by the flexiVent system. Results: The production of OVA-specific IgG1 and IgE was greater in the epicutaneously sensitized BALB/c than C57BL/6 mice. In contrast, both eosinophilic airway inflammation and bronchial responsiveness to methacholine were more prominent in the C57BL/6 than in the BALB/c mice. The concentrations of interleukin-4 increased significantly in the BALF from C57BL/6 mice only. No between-strain differences were observed after intraperitoneal sensitization. Conclusions: The C57BL/6 mouse is a more appropriate model than the BALB/c mouse to study the relationship between skin barrier dysfunction and the pathogenesis of allergic asthma.

Published
2010

4. Abstracts of Lectures at the Workshop

Author

Shuhei Fukuda, Masaya Yokota, Yuko Nakase, Sakura Sato, Takatsugu Komata, Hiroshi Uchi, Masutaka Furue, Ryuji Sato, Masahide Takeda, Isao Ohno, Kinya Nagata, Hiroyuki Nagase, Hiroyuki Hirai, Hiroyuki Ida, Satoshi Matsukura, Shintaro Suzuki, Druck Reinhardt Druck Basel, Yukiko Hiraguchi, Kenichi Maruyama, Takayuki Ohtomo, Koichiro Asano, Akira Nishi, Hiroshi Moriyama, Toshio Inoue, Takashi Iwanaga, Gail M. Kephart, Yusuke Suzuki, Akio Mori, Daiki Nakagomi, Motohiro Ebisawa, Takahiro Tsuburai, Naoya Sugimoto, Akemi Abe, Chisei Ra, Hirohito Kita, Shu Hashimoto, Takahito Chiba, Tasuku Kawano, Shu Imbe, Morimitsu Tomikawa, Shizuko Kagawa, Kotaro Suzuki, Mio Kawaguchi, Takachika Hiroi, Ichiro Nomura, Satz Mengensatzproduktion, Sho Matsushita, Mika Ogata, Kota Wada, Hidefumi Wakashin, Noriko Kitamura, Hiroshi Santo, Motoaki Takayanagi, Junji Yodoi, Katsuhito Iikura, Koa Hosoki, Toshiaki Kikuchi, Kazuma Iida, Reiko Tokuda, Tetsuya Shiomi, Hirohisa Saito, Takao Fujisawa, Koichi Sayama, Noriko Kobayashi, Fumiko Yasukawa, Toshio Katsunuma, Makiko Fukunaga, Naomi Tsurikisawa, Masataka Nakamura, Kosei Iguchi, Eiko Ito, Kazuo Ishikawa, Maho Suzukawa, Hirotoshi Kawashima, Makoto Nagata, Chikara Asaka, Saburo Saito, Mino Yoshioka, Yoshiyuki Yamada, Mizuho Nagao, Yasuhide Hayashi, Hiroko Takeuchi, Masao Yamaguchi, Naoko Fukui, Kaori Okuyama, Yuka Hamanaka, Hiroyuki Sano, Wataru Ito, Hideki Tatsumi, Soichi Nemoto, Takanori Imai, Chiyako Oshikata, Yuichi Ohkawara, Yasuhiro Gon, Kaiyu Han, Kazuo Akiyama, Masayuki Sato, Ken Ohta, Toshiaki Ihara, Yuji Tohda, Satoshi Koyama, Takehiro Higashi, Hiroshi Tachimoto, Noriko Hashimoto, Shin-itsu Hatakeyama, Tokuhiro Kimura, Junko Hirato, Rie Takagi, Kohei Honda, Yoshinori Matsuwaki, Masatsugu Kurokawa, Masamune Higashigawa, Hisashi Tanida, Koushi Ieki, Osamu Kaminuma, Kumiko Hashimoto, Takako Toda, Shigeharu Ueki, Hiroshi Nakajima, Hideki Yamamoto, Tetsuya Homma, Koichi Fukunaga, Munehiro Yamaguchi, Masahiko Kato, Shin Watanabe, Norio Suzuki, Miho Odaka, Akinori Shukuya, Yoshifumi Ebara, Mitsuru Adachi, Hiroaki Takatori, Arifumi Iwata, Hiroyuki Kayaba, Hiroshi Saito, Masato Muraki, Satoshi Nunomura, Kenji Matsumoto, Sadato Ichinohe, Hajime Nakamura, Junichi Chihara, Tsuyoshi Oguma, Hideaki Morita, and Shizuko Saika

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
2011
Full Text
View/download PDF

5. Subject Index Vol. 155, Suppl. 1, 2011

Author

Kinya Nagata, Satoshi Matsukura, Hiroshi Moriyama, Koichiro Asano, Kohei Honda, Yoshinori Matsuwaki, Takashi Iwanaga, Yusuke Suzuki, Gail M. Kephart, Akio Mori, Hiroyuki Kayaba, Morimitsu Tomikawa, Shin-itsu Hatakeyama, Shigeharu Ueki, Shizuko Kagawa, Takachika Hiroi, Tokuhiro Kimura, Koichi Fukunaga, Hiroshi Nakajima, Arifumi Iwata, Sakura Sato, Takatsugu Komata, Mika Ogata, Masahide Takeda, Daiki Nakagomi, Munehiro Yamaguchi, Kenji Matsumoto, Masutaka Furue, Akinori Shukuya, Chiyako Oshikata, Kazuo Akiyama, Takahito Chiba, Mino Yoshioka, Kenichi Maruyama, Noriko Kobayashi, Makoto Nagata, Toshiaki Ihara, Mizuho Nagao, Kaori Okuyama, Hiroshi Saito, Yukiko Hiraguchi, Chikara Asaka, Hiroyuki Hirai, Hiroyuki Ida, Toshio Inoue, Reiko Tokuda, Takao Fujisawa, Motohiro Ebisawa, Saburo Saito, Takayuki Ohtomo, Satz Mengensatzproduktion, Hiroyuki Sano, Koa Hosoki, Naoya Sugimoto, Kazuma Iida, Takako Toda, Masao Yamaguchi, Tetsuya Shiomi, Hiroko Takeuchi, Eiko Ito, Akira Nishi, Kaiyu Han, Kosei Iguchi, Junji Yodoi, Katsuhito Iikura, Naomi Tsurikisawa, Yuka Hamanaka, Sadato Ichinohe, Mio Kawaguchi, Hirotoshi Kawashima, Norio Suzuki, Yasuhide Hayashi, Masataka Nakamura, Mitsuru Adachi, Rie Takagi, Shintaro Suzuki, Druck Reinhardt Druck Basel, Soichi Nemoto, Ichiro Nomura, Noriko Kitamura, Kotaro Suzuki, Tasuku Kawano, Motoaki Takayanagi, Hirohito Kita, Noriko Hashimoto, Hirohisa Saito, Shu Imbe, Masato Muraki, Fumiko Yasukawa, Hidefumi Wakashin, Hiroshi Uchi, Kota Wada, Makiko Fukunaga, Satoshi Koyama, Masayuki Sato, Takehiro Higashi, Toshio Katsunuma, Sho Matsushita, Toshiaki Kikuchi, Hiroshi Santo, Tetsuya Homma, Koichi Sayama, Takahiro Tsuburai, Takanori Imai, Yuichi Ohkawara, Yasuhiro Gon, Kazuo Ishikawa, Shuhei Fukuda, Osamu Kaminuma, Kumiko Hashimoto, Wataru Ito, Hideki Tatsumi, Hiroshi Tachimoto, Hiroyuki Nagase, Ken Ohta, Junko Hirato, Hajime Nakamura, Isao Ohno, Shu Hashimoto, Junichi Chihara, Satoshi Nunomura, Tsuyoshi Oguma, Shin Watanabe, Hiroaki Takatori, Hideaki Morita, Akemi Abe, Chisei Ra, Shizuko Saika, Maho Suzukawa, Koushi Ieki, Masahiko Kato, Miho Odaka, Yoshifumi Ebara, Masaya Yokota, Yuko Nakase, Ryuji Sato, Yuji Tohda, Hisashi Tanida, Masatsugu Kurokawa, Masamune Higashigawa, Hideki Yamamoto, Yoshiyuki Yamada, and Naoko Fukui

Subjects
Gerontology, Index (economics), business.industry, Immunology, Immunology and Allergy, Medicine, Subject (documents), General Medicine, business
Published
2011
Full Text
View/download PDF

6. List of Lectures

Author

Nobufumi Kamiishi, Koichi Hirose, Shin-ichiro Kagami, Sakura Sato, Motohiro Kodama, Takehiko Sasaki, Akinori Shukuya, Kenji Matsumoto, Satoshi Nunomura, Shoichiro Miyatake, Robert P. Schleimer, Masahide Takeda, Jun Miyata, Tadashi Terui, Soichi Nemoto, Daisuke Kashiwakuma, Shintaro Suzuki, Yoshiyuki Yamada, Taku Miyasho, Satoshi Matsukura, Akemi Abe, Takehito Kobayashi, Koichiro Asano, Shin Watanabe, Teruaki Kimura, Miho Odaka, Noriaki Kobayashi, Kotaro Suzuki, Morimitsu Tomikawa, Shizuko Kagawa, Takachika Hiroi, Hiromi Ogura, Masatsugu Kurokawa, Tsukasa Ohnishi, Akio Mori, Hiroyuki Miyoshi, Takayuki Ohtomo, Katsuyoshi Tomomatsu, Yukiko Hiraguchi, Shunsuke Furuta, Hideo Wada, Yotaro Takaku, Misa Wakaki, Eiji Ikeda, Hikari Kato, Yoshihiro Oya, Hiroyuki Kayaba, Jose A. Cancelas, Kazuya Suzuki, Koushi Ieki, Mio Kawaguchi, Yasuhide Hayashi, Shuichi Yamamoto, Koichi Hagiwara, Chisei Ra, Takefumi Yamaguchi, Shuhei Fukuda, Takao Fujisawa, Tomohiro Utsunomiya, Itsuo Iwamoto, Osamu Kaminuma, Junji Yamada, Kei Ikeda, Tomomi Tanigai, Koichi Fukunaga, Makoto Nagata, Yoshitaka Okamoto, Hiroshi Tachimoto, Matsunobu Suko, Koa Hosoki, Takashi Hirose, Fujiko Kitamura, Tetsuya Homma, Maki Terakawa, Norimasa Kurosaka, Wataru Ito, Hiroko Kanari, Masako Tanabe, Hideki Tatsumi, Junichi Chihara, Tsuyoshi Oguma, Masamichi Iguchi, Yuko Kitahata, Kyuto Tanaka, Reiko Tokuda, Koichi Sayama, Akira Suto, Masayuki Sato, Kazuyuki Nakagome, Masahiko Kato, Motohiro Ebisawa, Soichiro Ueda, Noriyuki Yanagida, Akiko Nakamura, Takatsugu Komata, Fuyumi Nishihara, Minoru Kanazawa, Mizuho Nagao, Takanori Imai, Takahisa Takihara, Junko Kihara, Mitsuru Adachi, Norihiko Watanabe, Tsutomu Nobori, Nao Ohmori, Shigeharu Ueki, Hiroshi Nakajima, Kenichi Maruyama, Noriko Kitamura, Hirohisa Saito, Tomoyuki Soma, and Akitoshi Ishizaka

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
2010
Full Text
View/download PDF

7. Subject Index Vol. 152, Suppl. 1, 2010

Author

Kyuto Tanaka, Reiko Tokuda, Masamichi Iguchi, Daisuke Kashiwakuma, Tomoyuki Soma, Itsuo Iwamoto, Koichi Fukunaga, Teruaki Kimura, Hiromi Ogura, Koichi Hagiwara, Masatsugu Kurokawa, Akinori Shukuya, Masahiko Kato, Takehito Kobayashi, Yasuhide Hayashi, Soichiro Ueda, Satoshi Matsukura, Sakura Sato, Takatsugu Komata, Matsunobu Suko, Fuyumi Nishihara, Hiroko Kanari, Motohiro Ebisawa, Koichiro Asano, Eiji Ikeda, Masayuki Sato, Misa Wakaki, Yukiko Hiraguchi, Junichi Chihara, Yoshihiro Oya, Tsuyoshi Oguma, Tadashi Terui, Koichi Sayama, Noriaki Kobayashi, Nobufumi Kamiishi, Satoshi Nunomura, Mitsuru Adachi, Tsutomu Nobori, Akira Suto, Tsukasa Ohnishi, Akio Mori, Noriko Kitamura, Hideo Wada, Shuichi Yamamoto, Yotaro Takaku, Hirohisa Saito, Takefumi Yamaguchi, Hiroyuki Kayaba, Jose A. Cancelas, Miho Odaka, Takao Fujisawa, Junji Yamada, Chisei Ra, Mizuho Nagao, Hikari Kato, Takanori Imai, Kei Ikeda, Takehiko Sasaki, Osamu Kaminuma, Hiroyuki Miyoshi, Shoichiro Miyatake, Nao Ohmori, Wataru Ito, Hideki Tatsumi, Hiroshi Tachimoto, Tetsuya Homma, Koa Hosoki, Katsuyoshi Tomomatsu, Kotaro Suzuki, Takashi Hirose, Kenji Matsumoto, Tomohiro Utsunomiya, Kazuyuki Nakagome, Kazuya Suzuki, Yuko Kitahata, Tomomi Tanigai, Shigeharu Ueki, Maki Terakawa, Shin Watanabe, Yoshitaka Okamoto, Hiroshi Nakajima, Fujiko Kitamura, Norimasa Kurosaka, Masako Tanabe, Kenichi Maruyama, Shintaro Suzuki, Shuhei Fukuda, Koichi Hirose, Makoto Nagata, Shunsuke Furuta, Motohiro Kodama, Shin-ichiro Kagami, Yoshiyuki Yamada, Taku Miyasho, Koushi Ieki, Morimitsu Tomikawa, Akitoshi Ishizaka, Shizuko Kagawa, Takachika Hiroi, Akemi Abe, Takayuki Ohtomo, Mio Kawaguchi, Robert P. Schleimer, Masahide Takeda, Jun Miyata, Soichi Nemoto, Takahisa Takihara, Junko Kihara, Norihiko Watanabe, Noriyuki Yanagida, Akiko Nakamura, and Minoru Kanazawa

Subjects
Gerontology, Index (economics), Immunology, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results