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Start Over Author "Sandra A.C. Perez" Journal international archives of allergy and immunology
2 results on '"Sandra A.C. Perez"'

1. Contents, Vol. 102, 1993

Author

Antonella Teggi, N. Metaxotos, M.R. Rajasekar, Againdra K. Bewtra, P. Tsianakas, M. Weblacher, Anne Kagey-Sobotka, Hiroshi Matsuda, Chiharu Okada, M. Nakanishi, Kazuo Akiyama, J.A. Kirby, Franco De Rosa, Antonio Sebastiani, Dieter Kabelitz, Antonio Aceti, Marco A. Martins, W. Lowenstein, M. Yoshida, Tomoyo Matsubara, M. El-Mansoury, Ana M. Lamas, Radovan Borojevic, Susumu Furukawa, Keiko Kawamoto, Wei He, Haruhito Sugiyama, P. Stöger, Petrányi G, H. Ishii, K. Yagawa, W. Estelberger, A. Carabinis, K. Maninger, A. Balamotis, R. Letourneau, T. Dikeacou, A. Katsambas, Yasuaki Shimada, Patrícia M.R. e Silva, H. Tillian, G. Proud, H. Ogino, K. Schauenstein, Sandra A.C. Perez, C. Romana, Lucia M. Fondacaro, Ko Okumura, Keith A. Candiotti, O. Leri, Márcia C. El-Cheikh, Alfredo Pennica, W. Boucher, A. Leitsberger, J. Szebeni, M. Kawasaki, D. Celestino, Yukiyoshi Yanagihara, Hiroshi Saito, S. Hayashi, E. Schauenstein, Keijiro Yabuta, T.C. Theoharides, Robert G. Townley, Hiroko Ushio, E. Fragouli, Michele Columbo, Yukiko Kannan, R.M.R Taylor, Giuseppe Tacchi, M. Takayama, N. Renieri, B. Wüthrich, Takao Shida, B.K. Shenton, Renato S.B. Cordeiro, Takehiro Koshio, E. Horowitz, Lawrence M. Lichtenstein, Russell J. Hopp, J. Stratigos, Giorgio Quaranta, E. Kelemen, J.J. Rozniecki, Jane McKenzie-White, Marta Caferro, and Ryosuke Eda

Subjects
Pathology, medicine.medical_specialty, business.industry, Immunology, medicine, Immunology and Allergy, Physiology, General Medicine, business
Published
1993
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2. Eosinophil granulocyte proliferation induced by an intermediate factor generated in the pleural cavity of rats injected with platelet-activating factor-acether

Author

Sandra A.C. Perez, Márcia C. El-Cheikh, Marco A. Martins, Radovan Borojevic, Patrícia M.R. e Silva, and Renato S.B. Cordeiro

Subjects
Male, medicine.medical_treatment, Immunology, Granulocyte, Biology, Injections, chemistry.chemical_compound, Biological Factors, Bone Marrow, medicine, Immunology and Allergy, Eosinophilia, Animals, Platelet Activating Factor, Rats, Wistar, Cells, Cultured, Platelet-activating factor, Cell growth, Cell Differentiation, General Medicine, respiratory system, Pleural cavity, Eosinophil, In vitro, respiratory tract diseases, Rats, Eosinophils, medicine.anatomical_structure, Cytokine, chemistry, Cytokines, Pleura, Female, medicine.symptom, Cell Division
Abstract

In previous research, we have observed that intrathoracic administration of platelet-activating factor-acether (PAF) promoted a delayed eosinophilia in the pleural cavity of rats that lasted for at least 96 h. We investigated the ability of pleural washings from rats previously injected with PAF (1 micrograms/cavity) to stimulate in vitro murine hematopoietic eosinophil proliferation. We observed that pleural fluid sustained eosinophil proliferation but not differentiation, under conditions in which PAF itself had no effect. The phenomenon lasted for 3 days and was maximal on the 1st day of culture. Treatment with neutralizing antibodies against interleukin (IL)-5, granulocyte-macrophage colony-stimulating factor (GM-CSF) or IL-3, alone or in combination, did not modify the eosinophil proliferation induced by PAF pleural fluid, suggesting that these cytokines may not be involved in the studied phenomenon. We conclude that the rat pleural fluid obtained 6 h after PAF administration induces eosinophil proliferation in vitro by a mechanism probably independent of IL-5, GM-CSF or IL-3.

Published
1993

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