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Objective: Presenteeism has, in a larger sense, been viewed as a negative behaviour, although a limited body of studies suggests and reports its positive implications in an organizational context. This study assessed the association between the physical work environment (PWE) and presenteeism as well as the moderating influence of workplace support for health (WSH) on this relationship. Methods: This study adopted the cross-sectional design alongside a sensitivity analysis and techniques against common methods bias. The study population was employees of private and public organizations in Accra, Ghana. A total of 590 employees participated in the study and hierarchical linear regression was used to present the results. Results: PWE had a positive relationship with presenteeism (β = 0.15; t = 3.04; p < 0.05), which means that higher presenteeism was associated with larger PWE scores. WSH positively moderated the relationship between PWE and presenteeism (β = 0.23; t = 4.84; p < 0.001). Conclusions: Organizations with more satisfactory work environments may serve as preferred protective places for employees during a pandemic, more so within organizations with higher WSH. Interventions rolled out to improve PWE and to provide WSH can attenuate the potential negative influences of presenteeism on individual health and organizational productivity. [ABSTRACT FROM AUTHOR]