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Start Over Author "Marcus Taupp" Journal international biodeterioration & biodegradation
1 results on '"Marcus Taupp"'

1. Barbiturate-induced increase of biocatalytic hydroxylation and N-dealkylation of N,N-diethylaniline by whole-cell incubation with Bacillus megaterium

Author

Dag Harmsen, Frank Heckel, Peter Schreier, and Marcus Taupp

Subjects
biology, Stereochemistry, medicine.drug_class, Amobarbital, fungi, biology.organism_classification, Microbiology, Enzyme assay, Diethylaniline, Biomaterials, Hydroxylation, chemistry.chemical_compound, chemistry, Biotransformation, Barbiturate, biology.protein, medicine, bacteria, Phenobarbital, Waste Management and Disposal, medicine.drug, Bacillus megaterium
Abstract

Bacillus megaterium was used in biotransformation studies to test the influence of several barbiturates towards the recently observed N-dealkylation and arylic hydroxylation of N,N-diethylaniline. Certain barbiturates (phenobarbital and amobarbital) induced increased enzyme activity in whole-cell incubations with B. megaterium resulting in an increasing amount of N-deethylated and hydroxylated arylic (ortho- and para-hydroxylation) products, whereas ortho-hydroxylation was slightly favored. Phenobarbital did not show any effects towards hydroxylation activity, but N-dealkylation activity was highly induced. Finally, metyrapone highly reduced hydroxylation and N-dealkylation activity.

Published
2008
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