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With the increasing application of heat exchangers, the research has become increasingly comprehensive. Previous studies mainly focused on comparing the amplitudes to investigate the performance of heat exchangers, while the study of variable amplitude channel structures was limited. This study investigated the thermal-hydraulic performance of seven different sinusoidal channels with inclination angles of 20° and 30°, and their combinations. Using the CFD solver, simulations were conducted to assess the heat transfer capabilities of sinusoidal channels under various Reynolds numbers and different amplitude conditions, compared to straight channels and single amplitude sinusoidal channels. The results indicated that within one period, both the pressure drop and temperature difference exhibited a ripple trend of gradually decreasing amplitude. When evaluating the comprehensive performance of the channels, three trends emerged across the seven models, with the performance of the cold fluid and the hot fluid within the same group showing opposite trends. This suggested that more variations could enhance the overall performance of the hot fluid while reducing the performance of the cold fluid. For structures with the same amplitude, in terms of amplitude variation frequency, models with six periods per group exhibited higher overall heat transfer performance than those with three periods per group, with an average increase of 36.37%. For the arrangement of amplitudes (taking the hot fluid inlet as an example), configurations with a smaller amplitude at the inlet outperformed those with a larger amplitude, indicating that in combined amplitude models, a structure with a larger group and a smaller amplitude at the inlet (taking the hot fluid as an example) should be designed. [ABSTRACT FROM AUTHOR]