1. Plasma circulating tumor DNA testing in the management of HPV‐associated sinonasal and nasopharyngeal tumors.
- Author
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Im, Eunice, Kuan, Edward C., Adappa, Nithin D., Patel, Anil, and Chapurin, Nikita
- Subjects
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CIRCULATING tumor DNA , *HEAD & neck cancer , *PARANASAL sinuses , *PAPILLOMA , *TUMORS - Abstract
This article discusses the use of plasma circulating tumor DNA (ctDNA) testing in the management of HPV-associated sinonasal and nasopharyngeal tumors. The incidence of HPV-associated head and neck cancer has been increasing, and HPV-driven tumors commonly occur in the oropharynx and sinonasal tract. The management of HPV+ sinonasal carcinoma and HPV+ nasopharyngeal carcinoma is challenging, and better diagnostics are needed. Plasma ctDNA testing, also known as liquid biopsy, has shown promise in detecting the presence and recurrence of virus-induced tumors. It has been used successfully in the management of HPV+ oropharyngeal cancer and has the potential to improve the diagnosis and surveillance of HPV+ sinonasal and nasopharyngeal tumors. However, more research is needed to assess its efficacy in these specific tumor types. The article also discusses the methodology and cost analysis of plasma ctDNA testing and encourages clinicians to incorporate it into routine management of HPV+ sinonasal and nasopharyngeal tumors. [Extracted from the article]
- Published
- 2024
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