1. Sex disparities in outcomes among adults on long-term antiretroviral treatment in northern Nigeria
- Author
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Muktar H. Aliyu, Melynda Simmons, Ibrahim Nashabaru, Musa A. Garbati, Daiyabu A. Ibrahim, Baba Maiyaki Musa, Aisha M. Nalado, and Shehu M Yusuf
- Subjects
Adult ,Male ,0301 basic medicine ,Time Factors ,Health (social science) ,Adolescent ,Anti-HIV Agents ,Treatment outcome ,Nigeria ,HIV Infections ,Cohort Studies ,Young Adult ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Antiretroviral treatment ,Humans ,Medicine ,030212 general & internal medicine ,Young adult ,Generalized estimating equation ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Confounding ,Public Health, Environmental and Occupational Health ,Retrospective cohort study ,Original Articles ,General Medicine ,Middle Aged ,030112 virology ,Treatment Outcome ,Africa ,Immunology ,Female ,business ,Demography ,Cohort study ,Sex characteristics - Abstract
BACKGROUND There are conflicting reports of sex differences in HIV treatment outcomes in Africa. We investigated sex disparities in treatment outcomes for adults on first line antiretroviral treatment (ART) in Nigeria. METHODS We compared clinical and immunologic responses to ART between HIV-infected men (n=205) and women (n=140) enrolled in an ART program between June 2004 and December 2007, with follow-up through June 2014. We employed Kaplan-Meier estimates to examine differences in time to immunologic failure and loss to follow-up (LTFU), and generalized estimating equations to assess changes in CD4+ count by sex. RESULTS Men had lower baseline mean CD4+ count compared to women (327.6 cells/µL vs 413.4, respectively, p
- Published
- 2016
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