1. Arterial Stiffness Index and Exercise Tolerance in Patients Undergoing Cardiac Rehabilitation
- Author
-
Tetsuro Miyazaki, Kazunori Shimada, Shohei Ouchi, Masakazu Saitoh, Tetsuya Takahashi, Miho Nishitani-Yokoyama, Rie Matsumori, Abidan Abulimiti, Megumi Shimizu, Mitsuhiro Kunimoto, Hiroyuki Daida, Kosuke Fukao, Tomomi Matsubara, Miki Yamada, Tomoyuki Morisawa, Kei Fujiwara, Tatsuro Aikawa, Akio Honzawa, and Tohru Minamino
- Subjects
medicine.medical_specialty ,Ejection fraction ,business.industry ,VO2 max ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,respiratory tract diseases ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,Internal medicine ,Heart failure ,Bayesian multivariate linear regression ,medicine ,Cardiology ,Arterial stiffness ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,Anaerobic exercise ,circulatory and respiratory physiology - Abstract
Arterial stiffness contributes to the development of cardiovascular disease (CVD). However, the relationship between the arterial stiffness and exercise tolerance in CVD patients with preserved ejection fraction (pEF) and those with reduced EF (rEF) is unclear. We enrolled 358 patients who participated in cardiac rehabilitation and underwent cardiopulmonary exercise testing at Juntendo University Hospital. After excluding 195 patients who had undergone open heart surgery and 20 patients with mid-range EF, the patients were divided into pEF (n = 99) and rEF (n = 44) groups. Arterial stiffness was assessed using arterial velocity pulse index (AVI) and arterial pressure volume index (API) at rest. The patients in the pEF group were significantly older and had a higher prevalence of coronary artery disease than the rEF group. The pEF group had significantly lower AVI levels and higher API levels than the rEF group. In the pEF group, the peak oxygen uptake (peak VO2) and the anaerobic threshold was significantly higher than those in the rEF group. The peak VO2 was significantly and negatively correlated with AVI and API in the pEF group (All, P < 0.05), but not in the rEF group. Multivariate linear regression analyses demonstrated that AVI was independently associated with peak VO2 (β = -0.34, P < 0.05) in the pEF group. In conclusion, AVI may be a useful factor for assessing exercise tolerance, particularly in CVD patients with pEF.
- Published
- 2021
- Full Text
- View/download PDF