Search

Your search keyword '"Tracy L. Keiser"' showing total 2 results
Start Over Author "Tracy L. Keiser" Journal international immunology
2 results on '"Tracy L. Keiser"'

1. Immunity to protozoan parasite infection (PP-002)

Author

H. Watanabe, P. Salotra, A. Yano, Mohsen Abolhassani, Mohammad Hossein Alimohammadian, M. Abdul Hafeez, F. Afrin, H. M. Snider, Amir Mizbani, C. H. N. Costa, Ali Khamesipour, M. Razavi, H. Xia, A. Zavaran Hoseini, R. Burchmore, Christopher A. Hunter, M. Makino, R. Correa-Oliveira, C. Shimokawa, A. P. Barral, M. Narita, E. M. Silva, R. K. M. T. Bairam, A. M. Silva, H. Borges, K. Nagamune, M. Suzuki, P. Hagan, R. M. A. Carvalho, M. Nakaya, F. Jafari, Fabio T. M. Costa, M. A. H. Khan, N. Ohta, P. Guirnalda, L. S. Elias, K. Takeshima, K. Hirayama, R. S. Vaz, D. Dasgupta, Gerson Chadi, T. K. Khiong, L. Cui, I. Bechmann, V. Dara, A. Östlund Farrants, Tajie H. Harris, P. Giusti, R. H. Panatieri, S. Rebelo, J. Uzonna, L. I. A. Pereira, K. Suzue, E. N. Miller, K. Suzuki, J. S. Wiley, Arlene H. Sharpe, Y. Kitamura, S. M. B. Jeronimo, M. P. Lees, F. D. Pretel, C. D. Gowda, L. Renia, L. M. G. Bahia-Oliveira, M. M. Molaei, Joseph Barbi, J. Argueta, S. Kobayashi, Z. Mou, N. C. Smith, Kayhan Azadmanesh, L. C. Ndhlovu, Y. Beuzard, J. Chavatte, Caroline C. Whitacre, M. Tasleem, Stephanie Seveau, A. Dolo, P. Giri, S. I. Castillo-Mendéz, S. Ajdary, Farnaz Zahedifard, G. A. DosReis, Houri Rezvan, X. Olivares López, F. Aosai, S. G. Yasawardene, M. Akhtar, A. U. Haq, J. Tavares, Jude E. Uzonna, M. I. Hiyane, L. Gutiérrez-Kobeh, S. Hamano, R. L. Rocha, C. M. V. Vendrame, C. E. Rosas-Jorquera, B. Niang, M. Islamuddin, E. Vannier, M. Rasouli, Bahram Kazemi, N. Khansari, Samaneh Saberi, S. A. Kaba, S. Dias, B. Mbengue, M. Mauduit, Hiva Azizi, D. E. Lanar, N. R. Palha, A. Ferreira, H. Goto, B. Lu, A. Yoshida, Y. Hamzavi, Kazumi Norose, S. Soeng, A. Gorgin karaji, Y. Chinzei, G. K. Katara, A. Dieye, Luiz Roberto Sardinha, Nicholas Zorko, M. Troye-Blomberg, Karina R. Bortoluci, A. A. Oeij, O. Doumbo, Y. Yamaguchi, L. Castellucci, M. Takahashi, Tahere Taheri, A. Gruner, H. Yoshida, Yasaman Taslimi, B. S. Dwarakanath, S. Rojas Hernández, N. Ishii, K. Honma, A. A. A. Mohammady, A. Latifynia, A. Khodadadi, N. Vega Martínez, S. Koyasu, B. Malleret, Akitoshi Kikumura, M. F. Lopes, E. Houpt, Masoud Moradi, J. V. Weyenbergh, N. Uemura, R. M. Siegel, S. Magez, C. Brando, E. Salles, K. Sugamura, Y. Miyahira, M. Moroda, A. Shibuya, Q. Guo, M. M. Awais, Samar Kumar Guha, Tracy L. Keiser, D. Liu, S. Boström, B. Traoré, L. D. Souza, M. R. D'Império-Lima, W. F. Pereira, P. Burkhard, L. V. C. Guillermo, Carlos Penha-Gonçalves, M. Carrasco Yépez, C. Mittelholzer, C. M. Gomes, Abhay R. Satoskar, H. Daneshvar, H. Hara, A. Kanayama, M. Kayibanda, H. Maruyama, C. Arama, A. Asao, T. Tamura, M. Barral-Netto, N. T. Huy, H. Kamiabi, S. A. Pinto, C. Claser, José M. Alvarez, R. Ramasamy, T. Kanda-Taniguchi, M. Kikuchi, T. Susy, Lígia A. Gonçalves, F. Ginhoux, Abdolmajid Fata, Srijit Khan, H. Nekouie, M. L. Dorta, A. Lima-Neto, A. L. Peixoto-Rangel, M. R. D'Império Lima, V. Khase Shahgoli, H. Hisaeda, S. Black, A. Raz, V. Bockstal, K. Salgado, R. Campos Rodríguez, W. V. Parreira, S. Varani, T. Ono, C. A. Zago, M. Miyakoda, M. Nateghi-Rostami, L. C. Reis, M. Yamazaki, F. Montalvão, Sedigheh Zakeri, M. Doroudian, M. D. T. Carvalho, A. Henri, F. L. Ribeiro-Gomes, D. Kimura, A. Montes de Oca, V. Ramesh, E. M. Carvalho, B. Diatta, Danuta Radzioch, Patrick K. Reville, L. Roubaix, L. F. Batista, A. Cordeiro-da-Silva, Mojtaba Sankian, M. E. McCoy, G. Chouhan, J. M. Blackwell, M. Irfan Anwar, P. Teo, Rima McLeod, R. Udomsangpetch, M. P. Soares, M. Udagawa, Q. Gao, F. Ribeiro-Dias, B. L. Lima, K. Kimura, Y. Inamine, E. Belnoue, Â. Chora, N. D. Jadid, M. Yasunami, A. R. K. Goldberg, S. Hejazi, S. E. Jamieson, P. Bonilla-us, J. Kalil, Mahmoud Eshagh Hosseini, M. J. Gharagozlou, L. C. Oliveira, A. Alborzi, M. Mahmoudian Sani, N. S. Vellozo, A. Farooque, Mohammad Ali Nilforoushzadeh, S. R. Phillips, Q. Fang, T. Imai, T. Taniguchi, S. Phompida, I. Bujila, D. Iravani, P. Jia, I. Hussain, F. Ahmad, M. Senba, T. Yanagi, N. Hosseini, R. Perraut, S. J. Fuller, Hannah E. Cummings, S. Umemoto, M. K. Mannoor, K. Jangpatarapongsa, K. Yui, C. Li, A. Varasteh, T. A. P. F. Pimentel, D. L. Costa, F. A. Asteal, A. Barral, E. Ramos Sanchez, Kenji Shibuya, Sima Rafati, M. N. Shuaibu, Saqib Ali, Barbara Papadopoulou, G. K. Helegbe, Nastaran Ansari, J. Sattabongkot, S. Kiany, Christian Rommel, T. Wickramarachchi, H. H. Wortis, J. Yamada, M. Inahuku, F. Abrishami, P. V. Udagama-Randeniya, E. P. Amaral, F. Muhammad, Thomas Rückle, B. Li, M. Resende, A. Vigario, A. F. Frade, Y. Yang, André Luis Bombeiro, M. Yuda, P. Reville, G. Snounou, Craig Gerard, H. M. Niknam, M. A. P. Oliveira, T. Hoshino, R. G. Peixe, S. Zavosh, V. Thomaz-Soccol, S. Inam, and Graham H. Coombs

Subjects
Immunity, Immunology, Immunology and Allergy, General Medicine, Biology, Protozoan parasite, Microbiology
Published
2010

2. Genetic background influences immune responses and disease outcome of cutaneous L. mexicana infection in mice

Author

Abhay R. Satoskar, Anjali A. Satoskar, Tracy L. Keiser, Lucia E. Rosas, Jennifer Kaczmarek, Joseph Barbi, Claudio M. Lezama-Davila, and Alecia N. Septer

Subjects
Leishmania mexicana, Immunology, Ear infection, Leishmaniasis, Cutaneous, Antigens, Protozoan, Microbiology, Lesion, Mice, Immune system, Cutaneous leishmaniasis, parasitic diseases, medicine, Animals, Immunology and Allergy, Genetic Predisposition to Disease, Leishmania major, STAT6, Mice, Inbred BALB C, biology, General Medicine, biology.organism_classification, medicine.disease, Mice, Inbred C57BL, Kinetics, Mice, Inbred CBA, Cytokines, Lymph Nodes, medicine.symptom, STAT6 Transcription Factor, CD8
Abstract

The experimental model of high-dose Leishmania mexicana infection is used frequently to study molecular mechanisms regulating Th2 response since most inbred mice regardless of their genetic background display Th2 cytokine-dependent susceptibility to L. mexicana unlike Leishmania major. Here, we analyzed the course of L. mexicana infection in BALB/c, C57BL/6 and CBA/J mouse strains using low-dose ear infection model that mimics natural transmission. Although all three strains were equally susceptible to high-dose back rump L. mexicana infection, they displayed marked differences in their ability to control parasite growth after low-dose ear infection. Leishmania mexicana-infected BALB/c mice produced high levels of Th2-associated cytokines and developed non-healing lesions full of parasites, whereas CBA/J mice preferentially produced Th1-associated IFN-gamma but low levels of IL-4, and developed small self-resolving lesions. Both BALB/c and C57BL/6 mice produced comparable amounts of IFN-gamma following L. mexicana infection, but later produced less Th2-associated cytokines, and exhibited an 'intermediate' susceptibility phenotype characterized by lesion sizes that were significantly smaller than BALB/c mice but larger than CBA/J mice. Interestingly, all three strains also showed marked differences in trafficking of macrophages, CD4+ T cells and CD8+ T cells into their lesions. Finally, we analyzed the course of low-dose L. mexicana infection in signal transducers and activators of transcription (STAT) 6-/- and STAT6+/+ BALB/c mice. We found that STAT6-/- mice mount a Th1 response, produce high levels of IL-12 and IFN-gamma and develop smaller lesions containing fewer parasites as compared with STAT6+/+ mice. Our findings demonstrate that genetic background plays a critical role in determining susceptibility of inbred mice to low-dose L. mexicana infection. Furthermore, together with our previous findings, they show that STAT6-mediated signaling is involved in mediating susceptibility to L. mexicana following both high-dose back rump and low-dose ear dermis infection.

Published
2005

Catalog

Books, media, physical & digital resources
See catalog results