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Start Over Author "Wang, Xiaonan" Journal international immunopharmacology
10 results on '"Wang, Xiaonan"'

10. Rules to activate CD8 + T cells through regulating subunits of opioid receptors by methionine enkephalin (MENK).

Author

Jiao X, Wang X, Wang R, Geng J, Liu N, Chen H, Griffin N, and Shan F

Subjects
Animals, CD8-Positive T-Lymphocytes physiology, Mice, Mice, Inbred C57BL, Protein Subunits, Receptors, Opioid genetics, CD8-Positive T-Lymphocytes drug effects, Enkephalin, Methionine pharmacology, Gene Expression Regulation drug effects, Lymphocyte Activation drug effects, Neurotransmitter Agents pharmacology, Receptors, Opioid metabolism
Abstract

The goal of this work was to investigate how MENK could regulate the functions of CD8 + T cells and to explore the relationship between this regulation and opioid receptor expression. Our results showed that the opioid receptors presented on the cell menbrane of CD8 + T cells were MOR and DOR. MENK promoted the expression of opioid receptors as well as the elevation of the surface molecules such as CD28, PD-1, CTLA-4 and FasL and intracellular granzyme B. Selectively blocking the MOR by CTAP or DOR by NTI could result in inhibition of the corresponding CD8 + T cells proliferation and the expressions of surface molecules. In addition, non-selectively blocking both MOR and DOR by NTX could further impair the functions and proliferation of CD8 + T cells. Our currently data indicated that MENK could play a vital role in immune functions via precise regulation to subunits of opioid receptors., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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