1. YC-1 enhances natural killer cell differentiation from hematopoietic stem cells
- Author
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Yun, Sohyun, Lee, Suk Hyung, Kang, Yun Hee, Jeong, Mira, Kim, Mi Jeong, Kim, Mi Sun, Piao, Zheng-Hao, Suh, Hyun-Woo, Kim, Tae-don, Myung, Pyung-Keun, Yoon, Suk-Ran, and Choi, Inpyo
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THERAPEUTIC use of nitric oxide , *KILLER cells , *CELL differentiation , *HEMATOPOIETIC stem cells , *NATURAL immunity , *CELL growth , *CELLULAR signal transduction - Abstract
Abstract: NK cells play crucial roles in innate immunity and adaptive immunity. The detailed mechanisms, however, governing NK cell development remains unclear. In this study, we report that YC-1 significantly enhances NK cell populations differentiated from human umbilical cord blood hematopoietic stem cells (HSCs). NK cells increased by YC-1 display both phenotypic and functional features of fully mature NK (mNK) cells, but YC-1 does not affect the activation of mNK cells. YC-1 did not affect cGMP production and phosphorylation of STAT-5 which is essential for IL-15R signaling. On the other hand, YC-1 increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, p38 inhibitor SB203580 inhibited the differentiation of NK cells enhanced by YC-1. Taken together, these data suggest that YC-1 enhances NK cell differentiation through the activation of p38 MAPK which is involved in NK cell differentiation. [Copyright &y& Elsevier]
- Published
- 2010
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