1. Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health
- Author
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Karolina Törneke, Merja Rantala, Anja Holm, David Mackay, Jordi Torren Edo, Engeline van Duijkeren, Ernesto Liebana, Kornelia Grein, Cristina Muñoz Madero, Helen Jukes, Satu Pyörälä, Kari Grave, Keith E. Baptiste, Antonio López Navas, Anna-Pelagia Magiorakos, Miguel Angel Moreno Romo, Eric John Threlfall, Mair Powell, Marco Cavaleri, Boudewijn Catry, Pascal Sanders, Gérard Moulin, Maria Constança Matias Ferreira Pomba, Modestas Ružauskas, Christopher Teale, Institut Scientifique de Santé Publique [Belgique] - Scientific Institute of Public Health [Belgium] (WIV-ISP), Réseau International des Instituts Pasteur (RIIP), European Medicines Agency [London] (EMA), Danish Health and Medicines Agency, European Food Safety Authority = Autorité européenne de sécurité des aliments, European Centre for Disease Prevention and Control (ECDC), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Anses ANMV (Anses ANMV), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Université de Lisbonne, and University of Helsinki
- Subjects
Acinetobacter baumannii ,antibiotic resistance ,Polymyxin ,Antibiotics ,colistine ,résistance aux antibiotiques ,medicine.disease_cause ,polycyclic compounds ,Pharmacology (medical) ,media_common ,0303 health sciences ,biology ,Bacterial Infections ,General Medicine ,Antimicrobial ,Anti-Bacterial Agents ,3. Good health ,Europe ,Infectious Diseases ,Pseudomonas aeruginosa ,lipids (amino acids, peptides, and proteins) ,medicine.drug ,Microbiology (medical) ,medicine.medical_specialty ,medicine.drug_class ,Chemoprevention ,Microbiology ,03 medical and health sciences ,Antibiotic resistance ,[SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication ,Enterobacteriaceae ,Drug Resistance, Bacterial ,medicine ,Animals ,Humans ,media_common.cataloged_instance ,European Union ,European union ,Intensive care medicine ,030304 developmental biology ,[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health ,Colistin ,030306 microbiology ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,biology.organism_classification ,bacteria - Abstract
International audience; Since its introduction in the 1950s, colistin has been used mainly as a topical treatment in human medicine owing to its toxicity when given systemically. Sixty years later, colistin is being used as a last-resort drug to treat infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter baumannii and Enterobacteriaceae (e.g., Escherichia coli, Klebsiella pneumoniae), for which mortality can be high. In veterinary medicine, colistin has been used for decades for the treatment and prevention of infectious diseases. Colistin has been administered frequently as a group treatment for animal gastrointestinal infections caused by Gram-negative bacteria within intensive husbandry systems. Given the ever-growing need to retain the efficacy of antimicrobials used to treat MDR infections in humans, the use of colistin in veterinary medicine is being re-evaluated. Despite extensive use in veterinary medicine, there is limited evidence for the development of resistance to colistin and no evidence has been found for the transmission of resistance in bacteria that have been spread from animals to humans. Since surveillance for colistin resistance in animals is limited and the potential for such transmission exists, there is a clear need to reinforce systematic monitoring of bacteria from food-producing animals for resistance to colistin (polymyxins). Furthermore, colistin should only be used for treatment of clinically affected animals and no longer for prophylaxis of diseases, in line with current principles of responsible use of antibiotics.
- Published
- 2015
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