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Your search keyword '"Sun, Qian"' showing total 6 results
Start Over Author "Sun, Qian" Publication Year Range Last 3 years Language english Publication Type Academic Journals Journal international journal of biological macromolecules
6 results on '"Sun, Qian"'

6. The RNA-binding protein CSTF2 regulates BAD to inhibit apoptosis in glioblastoma.

Author

Xu, Yang, Yuan, Fanen, Sun, Qian, Zhao, Linyao, Hong, Yu, Tong, Shiao, Qi, Yangzhi, Ye, Liguo, Hu, Ping, Ye, Zhang, Zhang, Si, Liu, Baohui, and Chen, Qianxue

Subjects
*RNA-binding proteins, *GLIOBLASTOMA multiforme, *GENE expression, *CANCER cells, *APOPTOSIS
Abstract

RNA-binding proteins (RBP) regulate several aspects of co- and post-transcriptional gene expression in cancer cells. CSTF2 is involved in the expression of many cellular mRNAs and involved in the 3′-end cleavage and polyadenylation of pre-mRNAs to terminate transcription. However, the role of CSTF2 in human glioblastoma (GBM) and the underlying mechanisms remain unclear. In the present study, CSTF2 was found to be upregulated in GBM, and its high expression predicted poor prognosis. Knockdown CSTF2 induced GBM cell apoptosis both in vitro and in vivo. Specific mechanism studies showed that CSTF2 unstabilized the mRNA of the BAD protein by shortening its 3' UTR. Additionally, an increase in the expression level of CSTF2 decreased the expression level of BAD. In conclusion, CSTF2 binds to the mRNA of the BAD protein to shorten its 3'UTR, which negatively affects the BAD mediated apoptosis and promotes GBM cell survival. [ABSTRACT FROM AUTHOR]

Published
2023
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